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A genome-wide assoc...
A genome-wide association scan of RR and QT interval duration in 3 European genetically isolated populations : the EUROSPAN project
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Marroni, Fabio (author)
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Pfeufer, Arne (author)
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Aulchenko, Yurii S. (author)
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Franklin, Christopher S. (author)
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Isaacs, Aaron (author)
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Pichler, Irene (author)
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Wild, Sarah H. (author)
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Oostra, Ben A. (author)
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Wright, Alan F. (author)
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Campbell, Harry (author)
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Witteman, Jacqueline C. (author)
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Kääb, Stefan (author)
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Hicks, Andrew A. (author)
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- Gyllensten, Ulf (author)
- Uppsala universitet,Institutionen för genetik och patologi
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Rudan, Igor (author)
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Meitinger, Thomas (author)
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Pattaro, Cristian (author)
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van Duijn, Cornelia M. (author)
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Wilson, James F. (author)
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Pramstaller, Peter P. (author)
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(creator_code:org_t)
- 2009
- 2009
- English.
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In: Circulation: Cardiovascular Genetics. - 1942-3268. ; 2:4, s. 322-328
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- BACKGROUND: We set out to identify common genetic determinants of the length of the RR and QT intervals in 2325 individuals from isolated European populations. METHODS AND RESULTS: We analyzed the heart rate at rest, measured as the RR interval, and the length of the corrected QT interval for association with 318 237 single-nucleotide polymorphisms. The RR interval was associated with common variants within GPR133, a G-protein-coupled receptor (rs885389, P=3.9 x 10(-8)). The QT interval was associated with the earlier reported NOS1AP gene (rs2880058, P=2.00 x 10(-10)) and with a region on chromosome 13 (rs2478333, P=4.34 x 10(-8)), which is 100 kb from the closest known transcript LOC730174 and has previously not been associated with the length of the QT interval. CONCLUSIONS: Our results suggested an association between the RR interval and GPR133 and confirmed an association between the QT interval and NOS1AP.
Keyword
- genetics
- heart rate
- population
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Marroni, Fabio
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Pfeufer, Arne
-
Aulchenko, Yurii ...
-
Franklin, Christ ...
-
Isaacs, Aaron
-
Pichler, Irene
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show more...
-
Wild, Sarah H.
-
Oostra, Ben A.
-
Wright, Alan F.
-
Campbell, Harry
-
Witteman, Jacque ...
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Kääb, Stefan
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Hicks, Andrew A.
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Gyllensten, Ulf
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Rudan, Igor
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Meitinger, Thoma ...
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Pattaro, Cristia ...
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van Duijn, Corne ...
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Wilson, James F.
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Pramstaller, Pet ...
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show less...
- Articles in the publication
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Circulation: Car ...
- By the university
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Uppsala University