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Antithymocyte globu...
Antithymocyte globulin and cyclosporine A as combination therapy for low-risk non-sideroblastic myelodysplastic syndromes
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Broliden, Per Anders (author)
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Dahl, Inger-Marie (author)
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Hast, Robert (author)
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- Johansson, Bertil (author)
- Lund University,Lunds universitet,Avdelningen för klinisk genetik,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Clinical Genetics,Department of Laboratory Medicine,Faculty of Medicine
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Juvonen, Eeva (author)
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Kjeldsen, Lars (author)
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Porwit-MacDonald, Anna (author)
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Sjoo, Malvin (author)
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Tangen, Jon-Magnus (author)
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Uggla, Bertil (author)
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- Oberg, Gunnar (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper
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- Hellström-Lindberg, Eva (author)
- Karolinska Institutet
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(creator_code:org_t)
- 2006
- 2006
- English.
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In: Haematologica. - 0390-6078 .- 1592-8721. ; 91:5, s. 667-670
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http://www.haematolo... (free)
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https://urn.kb.se/re...
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https://lup.lub.lu.s...
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Abstract
Subject headings
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- The present study evaluated the combination of antithymocyte globulin (ATG) and cyclosporine A (CsA) in patients with low-risk myelodysplastic syndromes. Twenty patients (17 with refractory anemia and 3 with refractory anemia with excess blasts) received treatment with rabbit-ATG plus CsA. The overall response rate was 30% (6/20); three of the six responders had a complete response. The responses lasted 2-58 months, with two patients still being in complete remission at 42 and 58 months. Short-lasting cytogenetic remissions were achieved in two patients. ATG was poorly tolerated in patients over 70 years of age. Four out of 20 patients progressed to acute myeloid leukemia within a year. We conclude that immunosuppressive treatment may be a therapeutic option for selected patients with myelodysplastic syndrome.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
Keyword
- MDS
- ATG
- cyclosporine A
- treatment
- MEDICINE
- MEDICIN
- cyclosporine A
- MDS
- ATG
- treatment
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Broliden, Per An ...
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Dahl, Inger-Mari ...
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Hast, Robert
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Johansson, Berti ...
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Juvonen, Eeva
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Kjeldsen, Lars
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show more...
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Porwit-MacDonald ...
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Sjoo, Malvin
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Tangen, Jon-Magn ...
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Uggla, Bertil
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Oberg, Gunnar
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Hellström-Lindbe ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Hematology
- Articles in the publication
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Haematologica
- By the university
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Uppsala University
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Lund University
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Karolinska Institutet