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Enhancing influence...
Enhancing influence of intranasal interleukin-6 on slow-wave activity and memory consolidation during sleep
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- Benedict, Christian (author)
- Department of Neuroendocrinology, University of Lübeck, Lübeck, Germany
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Scheller, Jürgen (author)
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Rose-John, Stefan (author)
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Born, Jan (author)
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Marshall, Lisa (author)
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(creator_code:org_t)
- 2009-06-22
- 2009
- English.
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In: The FASEB Journal. - : FASEB. - 0892-6638 .- 1530-6860. ; 23:10, s. 3629-3636
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- The cytokine IL-6 has been considered to exert neuromodulating influences on the brain, with promoting influences on sleep. Sleep enhances the consolidation of memories, and, in particular, late nocturnal sleep also represents a period of enhanced IL-6 signaling, due to a distinctly enhanced availability of soluble IL-6 receptors during this period, enabling trans-signaling of IL-6 to neurons. Thus, a contribution of IL-6 to sleep-dependent memory consolidation is hypothesized. To test this hypothesis, we compared effects of intranasally administered IL-6 (vs. placebo) on sleep-dependent consolidation of declarative (neutral and emotional texts, 2-dimensional object location) and procedural (finger sequence tapping) memories in 17 healthy young men. IL-6 distinctly improved the sleep-related consolidation of emotional text material (P<0.03), which benefits mostly from sleep in the second night-half, in which rapid eye movement sleep (REM) dominates the non-REM-REM sleep cycle. During this second night-half, the amount of electroencephalogram slow-wave activity (0.5-4 Hz) distinctly increased after IL-6 (P<0.01). Other types of memory were not affected. The ability of IL-6 to enhance sleep-associated emotional memory consolidation highlights an example of a functional interaction between the central nervous and immune system.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- neuromodulation
- cytokine
- cognition
- electroencephalogram power
- MEDICINE
- MEDICIN
- Neuroscience
- Neurovetenskap
Publication and Content Type
- ref (subject category)
- art (subject category)
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