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Colocalization of oestrogen receptor immunoreactivity and preproenkephalin mRNA expression fo neurons in the superficial laminae of the spinal and medullary dorsal horn of rats

Amandusson, Åsa (author)
Linköpings universitet,Institutionen för biomedicin och kirurgi,Hälsouniversitetet
Hermanson, Ola (author)
Linköpings universitet,Institutionen för biomedicin och kirurgi,Hälsouniversitetet
Blomqvist, Anders (author)
Linköpings universitet,Institutionen för biomedicin och kirurgi,Hälsouniversitetet
 (creator_code:org_t)
Wiley InterScience, 1996
1996
English.
In: Eur J Neurosci. - : Wiley InterScience. ; 8:11, s. 2440-2445
  • Journal article (peer-reviewed)
Abstract Subject headings
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  • A double-labelling procedure combining immunohistochemical staining with in situ hybridization using a radiolabelled cRNA probe was employed to demonstrate oestrogen receptor-like immunoreactivity and preproenkephalin-A mRNA in the medullary and spinal dorsal horn of female rats. Both markers labelled large numbers of neurons in the substantia gelatinosa and its trigeminal homologue. Many of these neurons were double-labelled, displaying both oestrogen receptor-like-immunoreactivity and preproenkephalin-A mRNA; cell counts showed that 40-60% of the of the oestrogen receptor-like-immunoreactive cells in the superficial laminae also were labelled for preproenkephalin-A mRNA, and that 60-70% of the preproenkephalin-A mRNA-labelled neurons in the same laminae displayed oestrogen receptor-like immunoreactivity. Previous studies have shown that oestrogen receptors can bind to the promoter region of the preproenkephalin-A gene, and studies on the hypothalamus have demonstrated that oestrogen regulates enkephalin expression in select neuronal populations. The present results demonstrate that enkephalinergic neurons in the superficial dorsal horn contain oestrogen receptors and suggest that oestrogen may play an important role in the modulation of sensory and nociceptive processing in the lower medulla and spinal cord.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)

Keyword

Medical cell biology
Medicinsk cellbiologi
Medical Cell Biology
Medicinsk cellbiologi
Gonadal hormone enkephalin spinal cord
MEDICINE

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Amandusson, Åsa
Hermanson, Ola
Blomqvist, Ander ...
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MEDICAL AND HEALTH SCIENCES
MEDICAL AND HEAL ...
and Basic Medicine
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Uppsala University
Linköping University

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