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HLA-A alleles and i...
HLA-A alleles and infectious mononucleosis suggest a critical role for cytotoxic T-cell response in EBV-related Hodgkin lymphoma
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- Hjalgrim, Henrik (author)
- Karolinska Institutet
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Rostgaard, Klaus (author)
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Johnson, Paul C. D. (author)
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Lake, Annette (author)
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Shield, Lesley (author)
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Little, Ann-Margaret (author)
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- Ekström-Smedby, Karin (author)
- Karolinska Institutet
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Adami, Hans-Olov (author)
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- Glimelius, Bengt (author)
- Karolinska Institutet,Uppsala universitet,Institutionen för onkologi, radiologi och klinisk immunologi
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Hamilton-Dutoit, Stephen (author)
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Kane, Eleanor (author)
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Taylor, G. Malcolm (author)
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McConnachie, Alex (author)
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Ryder, Lars P. (author)
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Andersen, Paal Skytt (author)
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- Sundström, Christer (author)
- Uppsala universitet,Institutionen för immunologi, genetik och patologi
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Chang, Ellen T. (author)
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Alexander, Freda E. (author)
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Melbye, Mads (author)
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Jarrett, Ruth F. (author)
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(creator_code:org_t)
- 2010-03-22
- 2010
- English.
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In: Proceedings of the National Academy of Sciences of the United States of America. - : Proceedings of the National Academy of Sciences. - 0027-8424 .- 1091-6490. ; 107:14, s. 6400-6405
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http://www.pnas.org/...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- A proportion of classical Hodgkin lymphoma (HL) is believed to be causally related to infection with the ubiquitous lymphotropic EBV. The determining factors for development of EBV-related HL remain poorly understood, but likely involve immunological control of the viral infection. Accordingly, markers of the HLA class I region have been associated with risk of EBV-related HL. To study the host genetic component of EBV-related HL further, we investigated the lymphoma's association with HLA-A*01 and HLA-A*02 simultaneously in the setting of infectious mononucleosis (IM), a risk factor for EBV-related HL, in a case-series analysis including 278 EBV-related and 656 EBV-unrelated cases of HL. By logistic regression, HLA-A*01 alleles [odds ratio (OR) per allele, 2.15; 95% CI, 1.60-2.88] were associated with increased and HLA-A*02 alleles (OR per allele, 0.70; 95% CI, 0.51-0.97) with decreased risk of EBV-related HL. These allele-specific associations corresponded to nearly 10-fold variation in risk of EBV-related HL between HLA-A*01 and HLA-A*02 homozygotes. History of IM was also associated with risk of EBV-related HL (OR, 3.40; 95% CI, 1.74-6.66). The association between history of IM and EBV-related HL was not seen in the presence of HLA-A*02 because this allele appeared to neutralize the effect of IM on EBV-related HL risk. Our findings suggest that HLA class I-restricted EBV-specific cytotoxic T-cell responses and events in the early immune response to EBV infection in IM play critical roles in the pathogenesis of EBV-related HL.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Klinisk laboratoriemedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Clinical Laboratory Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine (hsv//eng)
Keyword
- Hodgkin lymphoma
- Haematology
- Hematologi
- Pathology
- Patologi
- Pathology
- Patologi
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Hjalgrim, Henrik
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Rostgaard, Klaus
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Johnson, Paul C. ...
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Lake, Annette
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Shield, Lesley
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Little, Ann-Marg ...
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show more...
-
Ekström-Smedby, ...
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Adami, Hans-Olov
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Glimelius, Bengt
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Hamilton-Dutoit, ...
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Kane, Eleanor
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Taylor, G. Malco ...
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McConnachie, Ale ...
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Ryder, Lars P.
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Andersen, Paal S ...
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Sundström, Chris ...
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Chang, Ellen T.
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Alexander, Freda ...
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Melbye, Mads
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Jarrett, Ruth F.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Hematology
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Cell and Molecul ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Clinical Laborat ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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Uppsala University
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Karolinska Institutet