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Quantitative assess...
Quantitative assessment of the subepithelial collagen band does not increase the accuracy of diagnosis of collagenous colitis
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- Rubio, Carlos A. (author)
- Karolinska Institutet
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Orrego, Abiel (author)
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- Höög, Anders (author)
- Karolinska Institutet
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Porwitz, Anja (author)
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Petersson, Fredrik (author)
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- Elmberger, Göran (author)
- Karolinska Institutet
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Glaessgen, Axel (author)
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Eriksson, Elina (author)
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- Kanter, Lena (author)
- Karolinska Institutet
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- Jaremko, Georg (author)
- Karolinska Institutet
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- Egevad, Lars (author)
- Karolinska Institutet
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Laforga, Juan (author)
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- Liljefors, M. (author)
- Karolinska Institutet
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- Löfdahl, Britta (author)
- Uppsala universitet,Institutionen för genetik och patologi
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Norman, Peter (author)
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- Larsson, Olle (author)
- Karolinska Institutet
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Wanat, Robert (author)
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Wejde, Johan (author)
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Zickert, Peter (author)
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- Björk, Jan (author)
- Karolinska Institutet
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Caini, Saverio (author)
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Palli, Domenico (author)
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Nesi, Gabriella (author)
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(creator_code:org_t)
- 2008
- 2008
- English.
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In: American Journal of Clinical Pathology. - 0002-9173 .- 1943-7722. ; 130:3, s. 375-381
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Abstract
Subject headings
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- The thickness of eosinophilic band in collagenous colitis (CC) was assessed by 3 methods: histologic estimates (22 observers), conventional measurements using a calibrated micrometric scale (1 observer), and semiautomatic micrometric measurements (1 observer). By the histologic estimate technique, 7.4% of the results failed to diagnose CC; by calibrated micrometry, the failure was 6% and by semiautomatic micrometry, 6%. The main difficulty in measuring the thickness of the CC band is that the deeper border of the band appears fuzzy and hairy-irregular. CC should be defined not exclusively on the basis of the thickness of the collagen table, but as a microscopic constellation characterized by a distorted superficial cell arrangement, with areas of epithelial denudation and inflammatory cells in the superficial epithelium and the lamina propria. In agreement with Lazenby's statement: "Focusing solely on the collagen band can result in both over- and underdiagnosis"
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Keyword
- collagenous colitis
- Gastroenterology
- Gastroenterologi
- Pathology
- Patologi
- Pathology
- Patologi
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Rubio, Carlos A.
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Orrego, Abiel
-
Höög, Anders
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Porwitz, Anja
-
Petersson, Fredr ...
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Elmberger, Göran
-
show more...
-
Glaessgen, Axel
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Eriksson, Elina
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Kanter, Lena
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Jaremko, Georg
-
Egevad, Lars
-
Laforga, Juan
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Liljefors, M.
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Löfdahl, Britta
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Norman, Peter
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Larsson, Olle
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Wanat, Robert
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Wejde, Johan
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Zickert, Peter
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Björk, Jan
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Caini, Saverio
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Palli, Domenico
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Nesi, Gabriella
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Gastroenterology ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Cell and Molecul ...
- Articles in the publication
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American Journal ...
- By the university
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Uppsala University
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Karolinska Institutet