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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 02749naa a2200469 4500 | |
| 001 | oai:DiVA.org:uu-12658 | |
| 003 | SwePub | |
| 008 | 080109s2007 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-126582 URI |
| 024 | 7 | a https://doi.org/10.1369/jhc.7A7282.20072 DOI |
| 040 | a (SwePub)uu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Jahangir Tafrechi, Roshan S.4 aut |
| 245 | 1 0 | a Single-cell A3243G mitochondrial DNA mutation load assays for segregation analysis |
| 264 | 1 | c 2007 |
| 338 | a print2 rdacarrier | |
| 520 | a Segregation of mitochondrial DNA (mtDNA) is an important underlying pathogenic factor in mtDNA mutation accumulation in mitochondrial diseases and aging, but the molecular mechanisms of mtDNA segregation are elusive. Lack of high-throughput single-cell mutation load assays lies at the root of the paucity of studies in which, at the single-cell level, mitotic mtDNA segregation patterns have been analyzed. Here we describe development of a novel fluorescence-based, non-gel PCR restriction fragment length polymorphism method for single-cell A3243G mtDNA mutation load measurement. Results correlated very well with a quantitative in situ Padlock/rolling circle amplification–based genotyping method. In view of the throughput and accuracy of both methods for single-cell A3243G mtDNA mutation load determination, we conclude that they are well suited for segregation analysis. | |
| 653 | a A3243G mtDNA | |
| 653 | a Aging | |
| 653 | a Heteroplasmy | |
| 653 | a Mitochondrial diseases | |
| 653 | a Mutation load | |
| 653 | a Padlock probing | |
| 653 | a PCR-RFLP | |
| 653 | a Segregation | |
| 653 | a MEDICINE | |
| 653 | a MEDICIN | |
| 700 | 1 | a van de Rijke, Frans M.4 aut |
| 700 | 1 | a Allalou, Aminu Uppsala universitet,Centrum för bildanalys,Datoriserad bildanalys4 aut0 (Swepub:uu)amial914 |
| 700 | 1 | a Larsson, Chatarinau Uppsala universitet,Institutionen för genetik och patologi4 aut0 (Swepub:uu)chlar838 |
| 700 | 1 | a Sloos, Willem C. R.4 aut |
| 700 | 1 | a van de Sande, Marchien4 aut |
| 700 | 1 | a Wählby, Carolinau Uppsala universitet,Centrum för bildanalys,Institutionen för genetik och patologi,Datoriserad bildanalys4 aut0 (Swepub:uu)cli05194 |
| 700 | 1 | a Janssen, George M. C.4 aut |
| 700 | 1 | a Raap, Anton K.4 aut |
| 710 | 2 | a Uppsala universitetb Centrum för bildanalys4 org |
| 773 | 0 | t Journal of Histochemistry and Cytochemistryg 55:11, s. 1159-1166q 55:11<1159-1166x 0022-1554x 1551-5044 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-12658 |
| 856 | 4 8 | u https://doi.org/10.1369/jhc.7A7282.2007 |
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