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Multicentre phase I...
Multicentre phase II studies evaluating imatinib plus hydroxyurea in patients with progressive glioblastoma
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Reardon, A (author)
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Dresemann, G (author)
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Taillibert, S (author)
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Campone, M (author)
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van den Bent, M (author)
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Clement, P (author)
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- Blomquist, E (author)
- Uppsala universitet,Institutionen för onkologi, radiologi och klinisk immunologi
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Gordower, L (author)
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Schultz, H (author)
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Raizer, J (author)
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Hau, P (author)
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Easaw, J (author)
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Gil, M (author)
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Tonn, J (author)
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Gijtenbeek, A (author)
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Schlegel, U (author)
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Bergstrom, P (author)
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Green, S (author)
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Weir, A (author)
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Nikolova, Z (author)
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(creator_code:org_t)
- 2009-11-10
- 2009
- English.
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In: British Journal of Cancer. - : Springer Science and Business Media LLC. - 0007-0920 .- 1532-1827. ; 101:12, s. 1995-2004
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https://www.nature.c...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- BACKGROUND: We evaluated the efficacy of imatinib mesylate in addition to hydroxyurea in patients with recurrent glioblastoma (GBM) who were either on or not on enzyme-inducing anti-epileptic drugs (EIAEDs). METHODS: A total of 231 patients with GBM at first recurrence from 21 institutions in 10 countries were enrolled. All patients received 500 mg of hydroxyurea twice a day. Imatinib was administered at 600 mg per day for patients not on EIAEDs and at 500 mg twice a day if on EIAEDs. The primary end point was radiographic response rate and secondary end points were safety, progression-free survival at 6 months (PFS-6), and overall survival (OS). RESULTS: The radiographic response rate after centralised review was 3.4%. Progression-free survival at 6 months and median OS were 10.6% and 26.0 weeks, respectively. Outcome did not appear to differ based on EIAED status. The most common grade 3 or greater adverse events were fatigue (7%), neutropaenia (7%), and thrombocytopaenia (7%). CONCLUSION: Imatinib in addition to hydroxyurea was well tolerated among patients with recurrent GBM but did not show clinically meaningful anti-tumour activity. British Journal of Cancer (2009) 101, 1995-2004. doi: 10.1038/sj.bjc.6605411 www.bjcancer.com Published online 10 November 2009 (C) 2009 Cancer Research UK
Keyword
- glioblastoma
- imatinib mesylate
- platelet-derived growth factor
- c-KIT
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Reardon, A
-
Dresemann, G
-
Taillibert, S
-
Campone, M
-
van den Bent, M
-
Clement, P
-
show more...
-
Blomquist, E
-
Gordower, L
-
Schultz, H
-
Raizer, J
-
Hau, P
-
Easaw, J
-
Gil, M
-
Tonn, J
-
Gijtenbeek, A
-
Schlegel, U
-
Bergstrom, P
-
Green, S
-
Weir, A
-
Nikolova, Z
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show less...
- Articles in the publication
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British Journal ...
- By the university
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Uppsala University