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Antiviral treatment...
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Holmberg, Rebecka
(author)
Antiviral treatments reduce severity of diabetes in Ljungan virus-infected CD-1 mice and delay onset in diabetes-prone BB rats
- Article/chapterEnglish2009
Publisher, publication year, extent ...
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Wiley,2009
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:uu-127514
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-127514URI
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https://doi.org/10.1111/j.1348-0421.2009.00160.xDOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:119396952URI
Supplementary language notes
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Language:English
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Summary in:English
Part of subdatabase
Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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The effects of LV in two different species, CD-1 mice, without a genetic disposition for diabetes, and BB rats prone to T1D were examined. Male CD-1 mice that had been exposed to LV in utero developed a type 2-like diabetes with increased blood glucose, insulin levels and epididymal fat at the age of 10-15 weeks. Combination therapy including LV-antiserum and an antiviral drug, Pleconaril, significantly reduced the levels of blood glucose and insulin and the amount of abdominal fat. In BB rats, LV has been found in both prediabetic- and diabetic diabetes-prone rats, as well as in diabetes-resistant rats. To evaluate whether the presence of LV has any influence on the onset of T1D, prediabetic BB rats were treated with an antiserum against LV or a combination of the antiviral drugs Pleconaril and Ribavirin. In the group treated with antiviral drugs, the onset was significantly delayed. These results indicate that the presence of LV can be involved in the pathogenesis of diabetes in these animal models.
Subject headings and genre
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antibody treatment
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antiviral therapy
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viral infection
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MEDICINE
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MEDICIN
Added entries (persons, corporate bodies, meetings, titles ...)
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Klitz, William
(author)
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Blixt, MartinUppsala universitet,Institutionen för medicinsk cellbiologi(Swepub:uu)mabli254
(author)
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Berggren, Per-OlofKarolinska Institutet
(author)
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Juntti-Berggren, LisaKarolinska Institutet
(author)
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Niklasson, BoUppsala universitet,Institutionen för medicinsk cellbiologi(Swepub:uu)boani125
(author)
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Uppsala universitetInstitutionen för medicinsk cellbiologi
(creator_code:org_t)
Related titles
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In:Microbiology and immunology: Wiley53:10, s. 567-5720385-56001348-0421
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