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Closing gaps in the...
Closing gaps in the human genome using sequencing by synthesis
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Garber, Manuel (author)
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- Zody, Michael C. (author)
- Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi
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Arachchi, M (author)
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Berlin, Aaron (author)
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Gnerre, Sante (author)
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Green, M (author)
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Lennon, Niall (author)
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Nusbaum, Chad (author)
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(creator_code:org_t)
- Springer Science and Business Media LLC, 2009
- 2009
- English.
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In: Genome Biology. - : Springer Science and Business Media LLC. - 1474-760X .- 1465-6906. ; 10:6, s. R60-
- Related links:
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https://genomebiolog...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- The most recent release of the finished human genome contains 260 euchromatic gaps (excluding chromosome Y). Recent work has helped explain a large number of these unresolved regions as 'structural' in nature. Another class of gaps is likely to be refractory to clone-based approaches, and cannot be approached in ways previously described. We present an approach for closing these gaps using 454 sequencing. As a proof of principle, we closed all three remaining non-structural gaps in chromosome 15.
Keyword
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
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