Closing gaps in the human genome using sequencing by synthesis

Garber, Manuel (author)

Zody, Michael C. (author): Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi

Arachchi, M (author)

Berlin, Aaron (author)

Gnerre, Sante (author)

Green, M (author)

Lennon, Niall (author)

Nusbaum, Chad (author)

(creator_code:org_t)

Springer Science and Business Media LLC, 2009
2009
English.
In: Genome Biology. - : Springer Science and Business Media LLC. - 1474-760X .- 1465-6906. ; 10:6, s. R60-

Related links:: https://genomebiolog...; show more...; https://urn.kb.se/re...; https://doi.org/10.1...; show less...

Abstract Subject headings

The most recent release of the finished human genome contains 260 euchromatic gaps (excluding chromosome Y). Recent work has helped explain a large number of these unresolved regions as 'structural' in nature. Another class of gaps is likely to be refractory to clone-based approaches, and cannot be approached in ways previously described. We present an approach for closing these gaps using 454 sequencing. As a proof of principle, we closed all three remaining non-structural gaps in chromosome 15.

By the author/editor: Garber, Manuel; Zody, Michael C.; Arachchi, M; Berlin, Aaron; Gnerre, Sante; Green, M; show more...; Lennon, Niall; Nusbaum, Chad; show less...

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