Recent advances in the genetics of autoimmune diseases

• Autoimmune diseases in general are complex genetic diseases where genes and environment interact in unknown ways. In recent years technologies have advanced our knowledge and new genes are being identified very rapidly. We can expect that most genes of major importance for the various autoimmune diseases will be discovered in the coming 5 years. The real challenge comes when we try to understand the mechanisms through which these genes confer disease susceptibility and how the interaction with environment takes place such that clinical expression of the disease results.

Keyword

systemic lupus erythematosus

inflammatory bowel disease

type 1 diabetes mellitus

rheumatoid arthritis

linkage

genetic association

single nucleotide polymorphisms

chromosomes

copy number variation

MEDICINE

MEDICIN

Publication and Content Type

ref (subject category)

kon (subject category)