Heart rate variability (HRV) in adolescent females with anxiety disorders and major depressive disorder

QC 20120210
AIM: The aim of this study was to investigate heart rate variability (HRV) in a clinical sample of female adolescents with anxiety disorders (AD) and/or major depressive disorder (MDD) compared with healthy controls and to assess the effect of selective serotonin reuptake inhibitors (SSRI) on HRV. METHODS: Heart rate variability was measured in adolescent female psychiatric patients with AD and/or MDD (n = 69), mean age 16.8 years (range: 14.5-18.4), from 13 out-patient clinics and in healthy controls (n = 65), mean age 16.5 years (range: 15.9-17.7). HRV was registered in the sitting position during 4 min with no interventions. RESULTS: Logarithmically transformed high frequency HRV (HF), low frequency HRV (LF) and standard deviation of inter beat intervals (SDNN) were lower in the clinical sample compared with the controls (Cohen's d for HF = 0.57, LF = 0.55, SDNN = 0.60). This was not explained by body mass index, blood pressure or physical activity. Medication with SSRI explained 15.5% of the total variance of HF, 3.0% of LF and 6.5% of SDNN. CONCLUSIONS: Adolescent female psychiatric patients with AD and/or MDD show reduced HRV compared with healthy controls. Medication with SSRI explained a part of this difference.

Olsson, ErikUppsala universitet,Institutionen för psykologi,Department of Psychology, Uppsala University, Uppsala, Swede(Swepub:uu)erols031 (author)
Serlachius, E.Karolinska Institutet (author)
Ericson, MatsFörsvarshögskolan(Swepub:fhs)10800 (author)
Ingvar, M.Karolinska Institutet (author)
Karolinska InstitutetInstitutionen för psykologi (creator_code:org_t)

By the author/editor: Henje Blom, Eva, ...; Olsson, Erik; Serlachius, E.; Ericson, Mats; Ingvar, M.

About the subject

By the university: Uppsala University; Umeå University; Royal Institute of Technology; Karolinska Institutet; Swedish National Defence College

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