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Trends in outcomes for very preterm infants in the southern region of Sweden over a 10-year period

Lundqvistt, Pia (author)
Lund University,Lunds universitet,Institutionen för experimentell medicinsk vetenskap,Medicinska fakulteten,Department of Experimental Medical Science,Faculty of Medicine
Källén, Karin (author)
Lund University,Lunds universitet,Tornbladinstitutet,Forskargrupper vid Lunds universitet,Tornblad Institute,Lund University Research Groups
Hallström, Inger (author)
Lund University,Lunds universitet,Institutionen för hälsovetenskaper,Medicinska fakulteten,Department of Health Sciences,Faculty of Medicine
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Hellström-Westas, Lena (author)
Lund University,Lunds universitet,Uppsala universitet,Institutionen för kvinnors och barns hälsa,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine
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 (creator_code:org_t)
Wiley, 2009
2009
English.
In: Acta Paediatrica. - : Wiley. - 0803-5253 .- 1651-2227. ; 98:4, s. 648-653
  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Aim: To investigate trends in mortality and morbidity in very preterm infants. Methods: Population-based perinatal register; liveborn infants 22 + 0 to 31 + 6 gestational weeks were investigated (time period 1995-2004). Time trends for mortality and common morbidities were explored using logistic regression analyses. Results: Data from 1614 liveborn infants were included. There was an increase in live born infants below 25 gestational weeks, annual odds ratio (OR) 1.15 (95% CI: 1.08-1.23) and a decrease in mortality annual OR 0.82 (95% CI: 0.69-0.98). The rates of bronchopulmonary dysplasia (BPD) and sepsis increased during the study period, annual ORs of 1.10 (95% CI: 1.04-1.17) and 1.09 (95% CI: 1.03-1.16). The duration of mechanical ventilation increased for surviving infants < 25 gestational weeks (p = 0.003), while the duration of continuous positive airway pressure (CPAP) increased for infants < 28 gestational weeks (p = < 0.001). There were no changes in the rates of intraventricular haemorrhages (IVH, 3-4), retinopathy of prematurity (ROP, 3-5), seizures or necrotizing enterocolitis (NEC). Conclusion: During the 10-year period changes in mortality and morbidity were most pronounced for infants with GA < 28 gestational weeks. The increasing rate of sepsis was present in infants < 28 gestational weeks, whereas the increase in BPD was demonstrated in the whole study population < 32 gestational weeks.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Pediatrik (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Pediatrics (hsv//eng)

Keyword

Bronchopulmonary dysplasia
Morbidity
Mortality
Preterm
Sepsis
Trend
MEDICINE
MEDICIN

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Lundqvistt, Pia
Källén, Karin
Hallström, Inger
Hellström-Westas ...
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MEDICAL AND HEALTH SCIENCES
MEDICAL AND HEAL ...
and Clinical Medicin ...
and Pediatrics
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Acta Paediatrica
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Uppsala University
Lund University

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