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Molecular and Evolu...
Molecular and Evolutionary History of Melanism in North American Gray Wolves
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Anderson, Tovi M. (author)
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vonHoldt, Bridgett M. (author)
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Candille, Sophie I. (author)
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Musiani, Marco (author)
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Greco, Claudia (author)
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Stahler, Daniel R. (author)
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Smith, Douglas W. (author)
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Padhukasahasram, Badri (author)
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Randi, Ettore (author)
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- Leonard, Jennifer A. (author)
- Uppsala universitet,Institutionen för evolutionsbiologi,Evolutionsbiologi
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Bustamante, Carlos D. (author)
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Ostrander, Elaine A. (author)
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Tang, Hua (author)
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Wayne, Robert K. (author)
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Barsh, Gregory S. (author)
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(creator_code:org_t)
- American Association for the Advancement of Science (AAAS), 2009
- 2009
- English.
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In: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 323:5919, s. 1339-1343
- Related links:
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https://europepmc.or...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Morphological diversity within closely related species is an essential aspect of evolution and adaptation. Mutations in the Melanocortin 1 receptor (Mc1r) gene contribute to pigmentary diversity in natural populations of fish, birds, and many mammals. However, melanism in the gray wolf, Canis lupus, is caused by a different melanocortin pathway component, the K locus, that encodes a beta-defensin protein that acts as an alternative ligand for Mc1r. We show that the melanistic K locus mutation in North American wolves derives from past hybridization with domestic dogs, has risen to high frequency in forested habitats, and exhibits a molecular signature of positive selection. The same mutation also causes melanism in the coyote, Canis latrans, and in Italian gray wolves, and hence our results demonstrate how traits selected in domesticated species can influence the morphological diversity of their wild relatives.
Subject headings
- NATURVETENSKAP -- Biologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences (hsv//eng)
Keyword
- Biology
- Biologi
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Anderson, Tovi M ...
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vonHoldt, Bridge ...
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Candille, Sophie ...
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Musiani, Marco
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Greco, Claudia
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Stahler, Daniel ...
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show more...
-
Smith, Douglas W ...
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Padhukasahasram, ...
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Randi, Ettore
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Leonard, Jennife ...
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Bustamante, Carl ...
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Ostrander, Elain ...
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Tang, Hua
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Wayne, Robert K.
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Barsh, Gregory S ...
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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Science
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Uppsala University