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  • Olsson, A.Karolinska Institutet (author)

Upregulation of bfl-1 is a potential mechanism of chemoresistance in B-cell chronic lymphocytic leukaemia

  • Article/chapterEnglish2007

Publisher, publication year, extent ...

  • 2007-08-28
  • Springer Science and Business Media LLC,2007
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-13000
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-13000URI
  • https://doi.org/10.1038/sj.bjc.6603951DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:115811638URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • B-cell chronic lymphocytic leukaemia (B-CLL) is characterised by the progressive accumulation of monoclonal CD5+ B cells. In a previous study, we have analysed the expression profile of apoptosis-regulating genes using a cDNA-based microarray and found overexpression of the antiapoptotic bcl-2 family member, bfl-1, in B-CLL cells with an apoptosis-resistant phenotype. In this study, bfl-1 mRNA levels have been determined by competitive PCR in an extended population of B-CLL patients to characterise its role in disease progression and development of chemoresistance. bfl-1 levels were significantly higher in patients with no response (NR) to last chemotherapy than in patients responding (partial response (PR)) to last chemotherapy (P<0.05) and in patients who had not required treatment (P<0.05). We found no correlation between bfl-1 mRNA levels and disease progression, IGHV mutational status or other clinical parameters. In addition, bfl-1 mRNA levels were inversely correlated with apoptotic response to in vitro fludarabine treatment of B-CLL cells. Specific downregulation of bfl-1 using siRNA induced apoptosis in resistant cells. Our data suggest that bfl-1 contributes to chemoresistance and might be a therapeutic target in B-CLL.

Subject headings and genre

  • Apoptosis
  • B-CLL
  • Bfl-1
  • Chemoresistance
  • MEDICINE
  • MEDICIN

Added entries (persons, corporate bodies, meetings, titles ...)

  • Norberg, MariaUppsala universitet,Institutionen för genetik och patologi(Swepub:uu)marno186 (author)
  • Ökvist, A. (author)
  • Derkow, K. (author)
  • Choudhury, A.Karolinska Institutet (author)
  • Tobin, GerardUppsala universitet,Institutionen för genetik och patologi (author)
  • Celsing, F. (author)
  • Österborg, A.Karolinska Institutet (author)
  • Rosenquist, RichardUppsala universitet,Institutionen för genetik och patologi(Swepub:uu)richrose (author)
  • Jondal, M.Karolinska Institutet (author)
  • Osorio, L. M.Karolinska Institutet (author)
  • Karolinska InstitutetInstitutionen för genetik och patologi (creator_code:org_t)

Related titles

  • In:British Journal of Cancer: Springer Science and Business Media LLC97:6, s. 769-7770007-09201532-1827

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