Search: onr:"swepub:oai:DiVA.org:uu-13011" >
The genomic landsca...
The genomic landscapes of human breast and colorectal cancers.
- Article/chapterEnglish2007
Publisher, publication year, extent ...
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American Association for the Advancement of Science (AAAS),2007
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:uu-13011
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-13011URI
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https://doi.org/10.1126/science.1145720DOI
Supplementary language notes
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Language:English
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Summary in:English
Part of subdatabase
Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Human cancer is caused by the accumulation of mutations in oncogenes and tumor suppressor genes. To catalog the genetic changes that occur during tumorigenesis, we isolated DNA from 11 breast and 11 colorectal tumors and determined the sequences of the genes in the Reference Sequence database in these samples. Based on analysis of exons representing 20,857 transcripts from 18,191 genes, we conclude that the genomic landscapes of breast and colorectal cancers are composed of a handful of commonly mutated gene "mountains" and a much larger number of gene "hills" that are mutated at low frequency. We describe statistical and bioinformatic tools that may help identify mutations with a role in tumorigenesis. These results have implications for understanding the nature and heterogeneity of human cancers and for using personal genomics for tumor diagnosis and therapy.
Subject headings and genre
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Animals
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Breast Neoplasms/*genetics/metabolism
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Cell Line
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Chromosome Mapping
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Colorectal Neoplasms/*genetics/metabolism
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Computational Biology
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DNA; Neoplasm
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Databases; Genetic
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Genes; Neoplasm
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Genome; Human
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Humans
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Metabolic Networks and Pathways/genetics
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Mice
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Mutation
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Neoplasm Proteins/genetics/metabolism
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Sequence Analysis; DNA
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MEDICINE
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MEDICIN
Added entries (persons, corporate bodies, meetings, titles ...)
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Parsons, D Williams
(author)
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Jones, Siân
(author)
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Lin, Jimmy
(author)
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Sjöblom, TobiasUppsala universitet,Institutionen för genetik och patologi,Sjöblom(Swepub:uu)tobisjob
(author)
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Leary, Rebecca J
(author)
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Shen, Dong
(author)
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Boca, Simina M
(author)
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Barber, Thomas
(author)
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Ptak, Janine
(author)
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Silliman, Natalie
(author)
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Szabo, Steve
(author)
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Dezso, Zoltan
(author)
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Ustyanksky, Vadim
(author)
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Nikolskaya, Tatiana
(author)
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Nikolsky, Yuri
(author)
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Karchin, Rachel
(author)
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Wilson, Paul A
(author)
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Kaminker, Joshua S
(author)
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Zhang, Zemin
(author)
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Croshaw, Randal
(author)
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Willis, Joseph
(author)
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Dawson, Dawn
(author)
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Shipitsin, Michail
(author)
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Willson, James K V
(author)
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Sukumar, Saraswati
(author)
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Polyak, Kornelia
(author)
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Park, Ben Ho
(author)
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Pethiyagoda, Charit L
(author)
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Pant, P V Krishna
(author)
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Ballinger, Dennis G
(author)
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Sparks, Andrew B
(author)
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Hartigan, James
(author)
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Smith, Douglas R
(author)
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Suh, Erick
(author)
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Papadopoulos, Nickolas
(author)
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Buckhaults, Phillip
(author)
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Markowitz, Sanford D
(author)
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Parmigiani, Giovanni
(author)
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Kinzler, Kenneth W
(author)
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Velculescu, Victor E
(author)
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Vogelstein, Bert
(author)
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Uppsala universitetInstitutionen för genetik och patologi
(creator_code:org_t)
Related titles
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In:Science: American Association for the Advancement of Science (AAAS)318:5853, s. 1108-11130036-80751095-9203
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Wood, Laura D
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Parsons, D Willi ...
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Jones, Siân
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Lin, Jimmy
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Sjöblom, Tobias
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Leary, Rebecca J
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Shen, Dong
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Boca, Simina M
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Barber, Thomas
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Ptak, Janine
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Silliman, Natali ...
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Szabo, Steve
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Dezso, Zoltan
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Ustyanksky, Vadi ...
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Nikolskaya, Tati ...
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Nikolsky, Yuri
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Karchin, Rachel
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Wilson, Paul A
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Kaminker, Joshua ...
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Zhang, Zemin
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Croshaw, Randal
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Willis, Joseph
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Dawson, Dawn
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Shipitsin, Micha ...
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Willson, James K ...
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Sukumar, Saraswa ...
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Polyak, Kornelia
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Park, Ben Ho
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Pethiyagoda, Cha ...
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Pant, P V Krishn ...
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Ballinger, Denni ...
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Sparks, Andrew B
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Hartigan, James
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Smith, Douglas R
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Suh, Erick
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Papadopoulos, Ni ...
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Buckhaults, Phil ...
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Markowitz, Sanfo ...
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Parmigiani, Giov ...
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Kinzler, Kenneth ...
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Velculescu, Vict ...
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Vogelstein, Bert
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Uppsala University