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Cystatin C Levels a...
Cystatin C Levels are Positively Correlated with both Aβ42 and Tau Levels in Cerebrospinal Fluid in Persons with Alzheimer's Disease, Mild Cognitive Impairment, and Healthy Controls
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- Sundelöf, Johan (author)
- Uppsala universitet,Geriatrik
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- Sundstrom, Johan (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper
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- Hansson, Oskar (author)
- Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups
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- Eriksdotter-Jönhagen, Maria (author)
- Karolinska Institutet
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- Giedraitis, Vilmantas (author)
- Uppsala universitet,Geriatrik
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- Larsson, Anders (author)
- Uppsala universitet,Klinisk kemi
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- Degerman-Gunnarsson, Malin (author)
- Uppsala universitet,Geriatrik
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- Ingelsson, Martin (author)
- Uppsala universitet,Geriatrik
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- Minthon, Lennart (author)
- Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups
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- Blennow, Kaj, 1958 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institutionen för biomedicin, avdelningen för klinisk kemi och transfusionsmedicin,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry,Institute of Biomedicine, Department of Clinical Chemistry and Transfusion Medicine
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- Kilander, Lena (author)
- Uppsala universitet,Geriatrik
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- Basun, Hans (author)
- Uppsala universitet,Geriatrik
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- Lannfelt, Lars (author)
- Uppsala universitet,Geriatrik
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- Luoto, Johannes (author)
- Lund University,Lunds universitet,Geriatrik,Forskargrupper vid Lunds universitet,Geriatric Medicine,Lund University Research Groups,Geriatrics
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(creator_code:org_t)
- 2010
- 2010
- English.
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In: Journal of Alzheimer's Disease. - 1387-2877 .- 1875-8908. ; 21:2, s. 471-478
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.3...
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https://gup.ub.gu.se...
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Abstract
Subject headings
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- Cystatin C is suggested to be involved in neurodegeneration and the development of Alzheimer's disease (AD) by binding to soluble amyloid-beta (Abeta) peptides. Studies of cystatin C levels in cerebrospinal fluid (CSF) in relation to risk of AD are conflicting and relations between cystatin C, Abeta42, and tau levels in CSF in AD, mild cognitive impairment (MCI), and healthy controls are unknown. The objective of this study was to investigate cystatin C, Abeta42, and tau levels in CSF in AD, MCI, and controls. As a secondary aim, the relationships between cystatin C, Abeta42, and tau levels across disease groups were investigated. Cystatin C, Abeta42, total tau, and phosphorylated tau levels in CSF were analyzed by turbidimetry (cystatin C) and xMAP Luminex technology (Abeta and tau) in persons with AD (n=101), MCI (n=84), and healthy control subjects (n=28). Mean cystatin C levels were similar in cases of AD (5.6 mumol/L +/- 1.7), MCI (5.4 mumol/L +/- 1.48), and controls (5.6 mumol/L +/- 1.6). However, CSF cystatin C levels were strongly and positively correlated with total tau and phosphorylated tau levels (r=0.61-0.81, p< 0.0001) and Abeta42 (r=0.35-0.65, p< 0.001) independent of age, gender, and APOE genotype. Mean CSF cystatin C levels did not differ between patients with AD and MCI and healthy controls. Interestingly, cystatin C levels were positively correlated with both tau and Abeta42 levels in CSF independent of age, gender, and APOE genotype.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
Keyword
- Alzheimer's disease
- biomarkers
- case control study
- cystatin C
- epidemiology
- risk factor
- MEDICINE
- MEDICIN
- epidemiology
- cystatin C
- case control study
- Alzheimer's disease
- biomarkers
- risk factor
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Sundelöf, Johan
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Sundstrom, Johan
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Hansson, Oskar
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Eriksdotter-Jönh ...
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Giedraitis, Vilm ...
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Larsson, Anders
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show more...
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Degerman-Gunnars ...
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Ingelsson, Marti ...
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Minthon, Lennart
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Blennow, Kaj, 19 ...
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Kilander, Lena
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Basun, Hans
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Lannfelt, Lars
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Luoto, Johannes
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Neurology
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Psychiatry
- Articles in the publication
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Journal of Alzhe ...
- By the university
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Uppsala University
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Lund University
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University of Gothenburg
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Karolinska Institutet