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  • Kriz, VitezslavUppsala universitet,Institutionen för medicinsk cellbiologi (author)

Shb null allele is inherited with a transmission ratio distortion and causes reduced viability in utero

  • Article/chapterEnglish2007

Publisher, publication year, extent ...

  • 2007
  • Wiley,2007
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-13084
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-13084URI
  • https://doi.org/10.1002/dvdy.21257DOI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • SHB is an Src homology 2 domain-containing adapter protein that has been found to be involved in numerous cellular responses. We have generated an Shb knockout mouse. No Shb-/- pups or embryos were obtained on the C57Bl6 background, indicating an early defect as a consequence of Shb- gene inactivation on this genetic background. Breeding heterozygotes for Shb gene inactivation (Shb+/-) on a mixed genetic background (FVB/C57Bl6/129Sv) reveals a distorted transmission ratio of the null allele with reduced numbers of Shb+/+ and Shb-/- animals, but increased number of Shb+/- animals. The Shb- allele is associated with various forms of malformations, explaining the relative reduction in the number of Shb-/- offspring. Shb-/- animals that were born were viable, fertile, and showed no obvious defects. However, Shb+/- female mice ovulated preferentially Shb- oocytes explaining the reduced frequency of Shb+/+ mice. Our study suggests a role of SHB during reproduction and development.

Subject headings and genre

  • Knockout
  • Malformations
  • Ovulation
  • SHB
  • Transmission ratio distortion
  • Viability in utero
  • MEDICINE
  • MEDICIN

Added entries (persons, corporate bodies, meetings, titles ...)

  • Mares, Jaroslav (author)
  • Wentzel, ParriUppsala universitet,Institutionen för medicinsk cellbiologi(Swepub:uu)parrwent (author)
  • Funa, Nina S.Uppsala universitet,Institutionen för medicinsk cellbiologi (author)
  • Calounova, GabrielaUppsala universitet,Institutionen för medicinsk cellbiologi(Swepub:uu)gabca335 (author)
  • Zhang, X-QUppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi(Swepub:uu)xiaozhan (author)
  • Forsberg-Nilsson, KarinUppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi(Swepub:uu)karifors (author)
  • Forsberg, MaudUppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi(Swepub:uu)mafor226 (author)
  • Welsh, MichaelUppsala universitet,Institutionen för medicinsk cellbiologi(Swepub:uu)michwels (author)
  • Uppsala universitetInstitutionen för medicinsk cellbiologi (creator_code:org_t)

Related titles

  • In:Developmental Dynamics: Wiley236:9, s. 2485-24921058-83881097-0177

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