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Connexin 26 (GJB2) ...
Connexin 26 (GJB2) mutations in two Swedish patients with atypical Vohwinkel (mutilating keratoderma plus deafness) and KID syndrome both extensively treated with acitretin
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- Bondeson, Marie-Louise (author)
- Uppsala universitet,Institutionen för genetik och patologi
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- Nyström, Anna-Maja (author)
- Uppsala universitet,Institutionen för genetik och patologi
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- Gunnarsson, Ulrika (author)
- Uppsala universitet,Institutionen för genetik och patologi
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- Vahlquist, Anders (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Dermatologi och venereologi
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(creator_code:org_t)
- Medical Journals Sweden AB, 2006
- 2006
- English.
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In: Acta Dermato-Venereologica. - : Medical Journals Sweden AB. - 0001-5555 .- 1651-2057. ; 86:6, s. 503-508
- Related links:
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https://doi.org/10.2...
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https://urn.kb.se/re...
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https://doi.org/10.2...
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Abstract
Subject headings
Close
- Neuroectodermal syndromes involving the skin and inner ear may be associated with mutations in connexin proteins, which form gap junctions important for intercellular communication. Vohwinkel syndrome (keratodermia mutilans with hearing loss) and keratitis-ichthyosis-deafness (KID) syndrome are rare ectodermal dysplasias associated with dominant mutations in the GJB2 gene encoding connexin 26. We report here two patients, one with KID and one with Vohwinkel syndrome. Both displayed unusual clinical features and responded well to long-term treatment with oral retinoid. Mutation analysis revealed a novel GJB2 mutation p.Gly59Ser in the patient with Vohwinkel syndrome, whereas a recurrent mutation (p.Asp50Asn) was found in the patient with KID syndrome. The clinical features, particularly a proneness to skin cancer in the patient with Vohwinkel syndrome, are discussed in relation to the identified genotypes.
Keyword
- Acitretin
- Cancer
- Cx26
- mutation
- Deafness
- Genodermatosis
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
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