Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Search: onr:"swepub:oai:DiVA.org:uu-131527" > Genetic variation i...

1 of 1
Previous record
Next record
To hitlist

Details
MARC

Saxena, Richa (author)

Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge

Article/chapterEnglish2010

Publisher, publication year, extent ...

2010-01-17
Springer Science and Business Media LLC,2010
printrdacarrier

Numbers

LIBRIS-ID:oai:DiVA.org:uu-131527
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-131527URI
https://doi.org/10.1038/ng.521DOI
https://lup.lub.lu.se/record/1569874URI
http://kipublications.ki.se/Default.aspx?queryparsed=id:120004916URI

Supplementary language notes

Language:English
Summary in:English

Part of subdatabase

SwePubSwePub

Classification

Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

Notes

Glucose levels 2 h after an oral glucose challenge are a clinical measure of glucose tolerance used in the diagnosis of type 2 diabetes. We report a meta-analysis of nine genome-wide association studies (n = 15,234 nondiabetic individuals) and a follow-up of 29 independent loci (n = 6,958–30,620). We identify variants at the GIPR locus associated with 2-h glucose level (rs10423928, β (s.e.m.) = 0.09 (0.01) mmol/l per A allele, P = 2.0 × 10−15). The GIPR A-allele carriers also showed decreased insulin secretion (n = 22,492; insulinogenic index, P = 1.0 × 10−17; ratio of insulin to glucose area under the curve, P = 1.3 × 10−16) and diminished incretin effect (n = 804; P = 4.3 × 10−4). We also identified variants at ADCY5 (rs2877716, P = 4.2 × 10−16), VPS13C (rs17271305, P = 4.1 × 10−8), GCKR (rs1260326, P = 7.1 × 10−11) and TCF7L2 (rs7903146, P = 4.2 × 10−10) associated with 2-h glucose. Of the three newly implicated loci (GIPR, ADCY5 and VPS13C), only ADCY5 was found to be associated with type 2 diabetes in collaborating studies (n = 35,869 cases, 89,798 controls, OR = 1.12, 95% CI 1.09–1.15, P = 4.8 × 10−18).

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Endokrinologi och diabetes hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Endocrinology and Diabetes hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Annan klinisk medicin hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Other Clinical Medicine hsv//eng
MEDICINE
MEDICIN

Added entries (persons, corporate bodies, meetings, titles ...)

Hivert, Marie-France (author)
Langenberg, Claudia (author)
Tanaka, Toshiko (author)
Pankow, James S (author)
Vollenweider, Peter (author)
Lyssenko, ValeriyaLund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups(Swepub:lu)endo-vly (author)
Bouatia-Naji, Nabila (author)
Dupuis, Josée (author)
Jackson, Anne U (author)
Kao, W H Linda (author)
Li, Man (author)
Glazer, Nicole L (author)
Manning, Alisa K (author)
Luan, Jian'an (author)
Stringham, Heather M (author)
Prokopenko, Inga (author)
Johnson, Toby (author)
Grarup, Niels (author)
Boesgaard, Trine W (author)
Lecoeur, Cécile (author)
Shrader, Peter (author)
O'Connell, Jeffrey (author)
Ingelsson, ErikKarolinska Institutet,Uppsala universitet,Geriatrik(Swepub:uu)ering425 (author)
Couper, David J (author)
Rice, Kenneth (author)
Song, Kijoung (author)
Andreasen, Camilla H (author)
Dina, Christian (author)
Köttgen, Anna (author)
Le Bacquer, Olivier (author)
Pattou, François (author)
Taneera, JalalLund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups(Swepub:lu)stem-jta (author)
Steinthorsdottir, Valgerdur (author)
Rybin, Denis (author)
Ardlie, Kristin (author)
Sampson, Michael (author)
Qi, Lu (author)
van Hoek, Mandy (author)
Weedon, Michael N (author)
Aulchenko, Yurii S (author)
Voight, Benjamin F (author)
Grallert, Harald (author)
Balkau, Beverley (author)
Bergman, Richard N (author)
Bielinski, Suzette J (author)
Bonnefond, Amelie (author)
Bonnycastle, Lori L (author)
Borch-Johnsen, Knut (author)
Böttcher, Yvonne (author)
Brunner, Eric (author)
Buchanan, Thomas A (author)
Bumpstead, Suzannah J (author)
Cavalcanti-Proença, Christine (author)
Charpentier, Guillaume (author)
Chen, Yii-Der Ida (author)
Chines, Peter S (author)
Collins, Francis S (author)
Cornelis, Marilyn (author)
J Crawford, Gabriel (author)
Delplanque, Jerome (author)
Doney, Alex (author)
Egan, Josephine M (author)
Erdos, Michael R (author)
Firmann, Mathieu (author)
Forouhi, Nita G (author)
Fox, Caroline S (author)
Goodarzi, Mark O (author)
Graessler, Jürgen (author)
Hingorani, Aroon (author)
Isomaa, Bo (author)
Jørgensen, Torben (author)
Kivimaki, Mika (author)
Kovacs, Peter (author)
Krohn, Knut (author)
Kumari, Meena (author)
Lauritzen, Torsten (author)
Lévy-Marchal, Claire (author)
Mayor, Vladimir (author)
McAteer, Jarred B (author)
Meyre, David (author)
Mitchell, Braxton D (author)
Mohlke, Karen L (author)
Morken, Mario A (author)
Narisu, Narisu (author)
Palmer, Colin N A (author)
Pakyz, Ruth (author)
Pascoe, Laura (author)
Payne, Felicity (author)
Pearson, Daniel (author)
Rathmann, Wolfgang (author)
Sandbaek, Annelli (author)
Sayer, Avan Aihie (author)
Scott, Laura J (author)
Sharp, Stephen J (author)
Sijbrands, Eric (author)
Singleton, Andrew (author)
Siscovick, David S (author)
Smith, Nicholas L (author)
Sparsø, Thomas (author)
Swift, Amy J (author)
Syddall, Holly (author)
Thorleifsson, Gudmar (author)
Tönjes, Anke (author)
Tuomi, Tiinamaija (author)
Tuomilehto, Jaakko (author)
Valle, Timo T (author)
Waeber, Gérard (author)
Walley, Andrew (author)
Waterworth, Dawn M (author)
Zeggini, Eleftheria (author)
Zhao, Jing Hua (author)
Illig, Thomas (author)
Wichmann, H Erich (author)
Wilson, James F (author)
van Duijn, Cornelia (author)
Hu, Frank B (author)
Morris, Andrew D (author)
Frayling, Timothy M (author)
Hattersley, Andrew T (author)
Thorsteinsdottir, Unnur (author)
Stefansson, Kari (author)
Nilsson, PeterLund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups(Swepub:lu)medf-pni (author)
Syvänen, Ann-ChristineUppsala universitet,Molekylär medicin(Swepub:uu)anncsyva (author)
Shuldiner, Alan R (author)
Walker, Mark (author)
Bornstein, Stefan R (author)
Schwarz, Peter (author)
Williams, Gordon H (author)
Nathan, David M (author)
Kuusisto, Johanna (author)
Laakso, Markku (author)
Cooper, Cyrus (author)
Marmot, Michael (author)
Ferrucci, Luigi (author)
Mooser, Vincent (author)
Stumvoll, Michael (author)
Loos, Ruth J F (author)
Altshuler, David (author)
Psaty, Bruce M (author)
Rotter, Jerome I (author)
Boerwinkle, Eric (author)
Hansen, Torben (author)
Pedersen, Oluf (author)
Florez, Jose C (author)
McCarthy, Mark I (author)
Boehnke, Michael (author)
Barroso, Inês (author)
Sladek, Robert (author)
Froguel, Philippe (author)
Meigs, James B (author)
Groop, LeifLund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups(Swepub:lu)endo-lgr (author)
Wareham, Nicholas J (author)
Watanabe, Richard M (author)
Genomik, diabetes och endokrinologiForskargrupper vid Lunds universitet (creator_code:org_t)

Related titles

In:Nature Genetics: Springer Science and Business Media LLC42:2, s. 142-1481061-40361546-1718

Internet link

Find in a library

Nature Genetics (Search for host publication in LIBRIS)

To the university's database

1 of 1
Previous record
Next record
To hitlist

Find more in SwePub

By the author/editor: Saxena, Richa; Hivert, Marie-Fr ...; Langenberg, Clau ...; Tanaka, Toshiko; Pankow, James S; Vollenweider, Pe ...; show more...; Lyssenko, Valeri ...; Bouatia-Naji, Na ...; Dupuis, Josée; Jackson, Anne U; Kao, W H Linda; Li, Man; Glazer, Nicole L; Manning, Alisa K; Luan, Jian'an; Stringham, Heath ...; Prokopenko, Inga; Johnson, Toby; Grarup, Niels; Boesgaard, Trine ...; Lecoeur, Cécile; Shrader, Peter; O'Connell, Jeffr ...; Ingelsson, Erik; Couper, David J; Rice, Kenneth; Song, Kijoung; Andreasen, Camil ...; Dina, Christian; Köttgen, Anna; Le Bacquer, Oliv ...; Pattou, François; Taneera, Jalal; Steinthorsdottir ...; Rybin, Denis; Ardlie, Kristin; Sampson, Michael; Qi, Lu; van Hoek, Mandy; Weedon, Michael ...; Aulchenko, Yurii ...; Voight, Benjamin ...; Grallert, Harald; Balkau, Beverley; Bergman, Richard ...; Bielinski, Suzet ...; Bonnefond, Ameli ...; Bonnycastle, Lor ...; Borch-Johnsen, K ...; Böttcher, Yvonne; Brunner, Eric; Buchanan, Thomas ...; Bumpstead, Suzan ...; Cavalcanti-Proen ...; Charpentier, Gui ...; Chen, Yii-Der Id ...; Chines, Peter S; Collins, Francis ...; Cornelis, Marily ...; J Crawford, Gabr ...; Delplanque, Jero ...; Doney, Alex; Egan, Josephine ...; Erdos, Michael R; Firmann, Mathieu; Forouhi, Nita G; Fox, Caroline S; Goodarzi, Mark O; Graessler, Jürge ...; Hingorani, Aroon; Isomaa, Bo; Jørgensen, Torbe ...; Kivimaki, Mika; Kovacs, Peter; Krohn, Knut; Kumari, Meena; Lauritzen, Torst ...; Lévy-Marchal, Cl ...; Mayor, Vladimir; McAteer, Jarred ...; Meyre, David; Mitchell, Braxto ...; Mohlke, Karen L; Morken, Mario A; Narisu, Narisu; Palmer, Colin N ...; Pakyz, Ruth; Pascoe, Laura; Payne, Felicity; Pearson, Daniel; Rathmann, Wolfga ...; Sandbaek, Annell ...; Sayer, Avan Aihi ...; Scott, Laura J; Sharp, Stephen J; Sijbrands, Eric; Singleton, Andre ...; Siscovick, David ...; Smith, Nicholas ...; Sparsø, Thomas; Swift, Amy J; Syddall, Holly; Thorleifsson, Gu ...; Tönjes, Anke; Tuomi, Tiinamaij ...; Tuomilehto, Jaak ...; Valle, Timo T; Waeber, Gérard; Walley, Andrew; Waterworth, Dawn ...; Zeggini, Elefthe ...; Zhao, Jing Hua; Illig, Thomas; Wichmann, H Eric ...; Wilson, James F; van Duijn, Corne ...; Hu, Frank B; Morris, Andrew D; Frayling, Timoth ...; Hattersley, Andr ...; Thorsteinsdottir ...; Stefansson, Kari; Nilsson, Peter; Syvänen, Ann-Chr ...; Shuldiner, Alan ...; Walker, Mark; Bornstein, Stefa ...; Schwarz, Peter; Williams, Gordon ...; Nathan, David M; Kuusisto, Johann ...; Laakso, Markku; Cooper, Cyrus; Marmot, Michael; Ferrucci, Luigi; Mooser, Vincent; Stumvoll, Michae ...; Loos, Ruth J F; Altshuler, David; Psaty, Bruce M; Rotter, Jerome I; Boerwinkle, Eric; Hansen, Torben; Pedersen, Oluf; Florez, Jose C; McCarthy, Mark I; Boehnke, Michael; Barroso, Inês; Sladek, Robert; Froguel, Philipp ...; Meigs, James B; Groop, Leif; Wareham, Nichola ...; Watanabe, Richar ...; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Endocrinology an ...

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Other Clinical M ...

Articles in the publication: Nature Genetics

By the university: Uppsala University; Lund University; Karolinska Institutet

Search outside SwePub

Extend your search to:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se