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Association of EBF1...
Association of EBF1, FAM167A(C8orf13)-BLK and TNFSF4 gene variants with primary Sjögren's syndrome
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- Nordmark, Gunnel (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Section of Rheumatology,Uppsala University
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- Kristjansdottir, Gudlaug (author)
- Uppsala universitet,Molekylär medicin,Section of Rheumatology,Uppsala University
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- Theander, Elke (author)
- Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Department of Clinical Sciences, Malmö,Faculty of Medicine,Malmö University Hospital
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- Appel, S. (author)
- University of Bergen, Norway,Uppsala University
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- Eriksson, Per (author)
- Östergötlands Läns Landsting,Linköpings universitet,Reumatologi,Hälsouniversitetet,Njurmedicinska kliniken US
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- Vasaitis, Lilian (author)
- Uppsala universitet,Reumatologi,Section of Rheumatology,Uppsala University
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- Kvarnström, M. (author)
- Karolinska Institutet,Karolinska Institutet, Stockholm
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- Delaleu, N. (author)
- University of Bergen, Norway
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- Lundmark, Per (author)
- Linköpings universitet,Uppsala universitet,Molekylär medicin,Reumatologi,Hälsouniversitetet
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- Lundmark, Anders (author)
- Linköpings universitet,Uppsala universitet,Molekylär medicin,Reumatologi,Hälsouniversitetet
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- Sjöwall, Christopher (author)
- Östergötlands Läns Landsting,Linköpings universitet,Reumatologi,Hälsouniversitetet,Reumatologiska kliniken i Östergötland
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- Brun, J. G. (author)
- Haukeland Hospital, Bergen, Norway
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- Jonsson, M. V. (author)
- University of Bergen, Norway
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- Harboe, E. (author)
- Stavanger University Hospital, Norway
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- Gøransson, L. G. (author)
- Stavanger University Hospital, Norway
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- Johnsen, S. J. (author)
- Stavanger University Hospital, Norway
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- Söderkvist, Peter (author)
- Linköpings universitet,Cellbiologi,Hälsouniversitetet
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- Eloranta, Maija-Leena (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Section of Rheumatology,Uppsala University
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- Alm, Gunnar (author)
- Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Inst för biomedicin och veterinär folkhälsovetenskap,Department of Biomedical Science and Veterinary Public Health,Swedish University of Agricultural Sciences, Uppsala
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- Baecklund, Eva (author)
- Uppsala universitet,Reumatologi,Section of Rheumatology,Uppsala University
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- Wahren-Herlenius, M. (author)
- Karolinska Institutet,Karolinska Institutet, Stockholm
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- Omdal, R. (author)
- Stavanger University Hospital, Norway
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- Rönnblom, Lars (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Section of Rheumatology,Uppsala University
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- Jonsson, R. (author)
- University of Bergen, Norway
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- Syvänen, Ann-Christine (author)
- Uppsala universitet,Molekylär medicin
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(creator_code:org_t)
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- 2010-09-23
- 2011
- English.
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In: Genes and Immunity. - : Springer Science and Business Media LLC. - 1466-4879 .- 1476-5470. ; 12:2, s. 100-109
- Related links:
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http://dx.doi.org/10...
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https://doi.org/10.1...
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https://res.slu.se/i...
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https://lup.lub.lu.s...
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Abstract
Subject headings
Close
- We performed a candidate gene association study in 540 patients with primary Sjögren's Syndrome (SS) from Sweden (n=344) and Norway (n=196) and 532 controls (n=319 Swedish, n=213 Norwegian). A total of 1139 single-nucleotide polymorphisms (SNPs) in 84 genes were analyzed. In the meta-analysis of the Swedish and Norwegian cohorts, we found high signals for association between primary SS and SNPs in three gene loci, not previously associated with primary SS. These are the early B-cell factor 1 (EBF1) gene, P=9.9 × 10−5, OR 1.68, the family with sequence similarity 167 member A–B-lymphoid tyrosine kinase (FAM167A–BLK) locus, P=4.7 × 10−4, OR 1.37 and the tumor necrosis factor superfamily (TNFSF4=Ox40L) gene, P=7.4 × 10−4, OR 1.34. We also confirmed the association between primary SS and the IRF5/TNPO3 locus and the STAT4 gene. We found no association between the SNPs in these five genes and the presence of anti-SSA/anti-SSB antibodies. EBF1, BLK and TNFSF4 are all involved in B-cell differentiation and activation, and we conclude that polymorphisms in several susceptibility genes in the immune system contribute to the pathogenesis of primary SS.
Subject headings
- NATURVETENSKAP -- Biologi -- Immunologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Immunology (hsv//eng)
- NATURVETENSKAP -- Biologi -- Genetik (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Genetics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Keyword
- primary Sjogren's syndrome
- candidate genes
- SNP
- EBF1
- BLK
- TNFSF4
- Rheumatology
- Reumatologi
- Medicin
- Medicine
- primary Sjogren's syndrome
- candidate genes
- SNP
- EBF1
- BLK
- TNFSF4
- MEDICINE
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
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Nordmark, Gunnel
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Kristjansdottir, ...
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Theander, Elke
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Appel, S.
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Eriksson, Per
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Vasaitis, Lilian
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show more...
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Kvarnström, M.
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Delaleu, N.
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Lundmark, Per
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Lundmark, Anders
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Sjöwall, Christo ...
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Brun, J. G.
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Jonsson, M. V.
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Harboe, E.
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Gøransson, L. G.
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Johnsen, S. J.
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Söderkvist, Pete ...
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Eloranta, Maija- ...
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Alm, Gunnar
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Baecklund, Eva
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Wahren-Herlenius ...
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Omdal, R.
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Rönnblom, Lars
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Jonsson, R.
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Syvänen, Ann-Chr ...
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show less...
- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Immunology
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Genetics
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
- Articles in the publication
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Genes and Immuni ...
- By the university
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Uppsala University
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Swedish University of Agricultural Sciences
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Lund University
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Karolinska Institutet
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Linköping University