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Association of EBF1...
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Nordmark, GunnelUppsala universitet,Institutionen för medicinska vetenskaper,Section of Rheumatology,Uppsala University
(author)
Association of EBF1, FAM167A(C8orf13)-BLK and TNFSF4 gene variants with primary Sjögren's syndrome
- Article/chapterEnglish2011
Publisher, publication year, extent ...
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2010-09-23
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Springer Science and Business Media LLC,2011
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:uu-131535
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-131535URI
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https://doi.org/10.1038/gene.2010.44DOI
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https://res.slu.se/id/publ/47175URI
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https://lup.lub.lu.se/record/1869304URI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:122081732URI
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-75912URI
Supplementary language notes
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Language:English
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Summary in:English
Part of subdatabase
Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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We performed a candidate gene association study in 540 patients with primary Sjögren's Syndrome (SS) from Sweden (n=344) and Norway (n=196) and 532 controls (n=319 Swedish, n=213 Norwegian). A total of 1139 single-nucleotide polymorphisms (SNPs) in 84 genes were analyzed. In the meta-analysis of the Swedish and Norwegian cohorts, we found high signals for association between primary SS and SNPs in three gene loci, not previously associated with primary SS. These are the early B-cell factor 1 (EBF1) gene, P=9.9 × 10−5, OR 1.68, the family with sequence similarity 167 member A–B-lymphoid tyrosine kinase (FAM167A–BLK) locus, P=4.7 × 10−4, OR 1.37 and the tumor necrosis factor superfamily (TNFSF4=Ox40L) gene, P=7.4 × 10−4, OR 1.34. We also confirmed the association between primary SS and the IRF5/TNPO3 locus and the STAT4 gene. We found no association between the SNPs in these five genes and the presence of anti-SSA/anti-SSB antibodies. EBF1, BLK and TNFSF4 are all involved in B-cell differentiation and activation, and we conclude that polymorphisms in several susceptibility genes in the immune system contribute to the pathogenesis of primary SS.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Kristjansdottir, GudlaugUppsala universitet,Molekylär medicin,Section of Rheumatology,Uppsala University
(author)
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Theander, ElkeLund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Department of Clinical Sciences, Malmö,Faculty of Medicine,Malmö University Hospital(Swepub:lu)medf-eth
(author)
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Appel, S.University of Bergen, Norway,Uppsala University
(author)
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Eriksson, PerÖstergötlands Läns Landsting,Linköpings universitet,Reumatologi,Hälsouniversitetet,Njurmedicinska kliniken US(Swepub:liu)perer22
(author)
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Vasaitis, LilianUppsala universitet,Reumatologi,Section of Rheumatology,Uppsala University(Swepub:uu)lilva850
(author)
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Kvarnström, M.Karolinska Institutet,Karolinska Institutet, Stockholm
(author)
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Delaleu, N.University of Bergen, Norway
(author)
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Lundmark, PerLinköpings universitet,Uppsala universitet,Molekylär medicin,Reumatologi,Hälsouniversitetet(Swepub:uu)pelun425
(author)
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Lundmark, AndersLinköpings universitet,Uppsala universitet,Molekylär medicin,Reumatologi,Hälsouniversitetet(Swepub:uu)andlu294
(author)
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Sjöwall, ChristopherÖstergötlands Läns Landsting,Linköpings universitet,Reumatologi,Hälsouniversitetet,Reumatologiska kliniken i Östergötland(Swepub:liu)chrsj93
(author)
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Brun, J. G.Haukeland Hospital, Bergen, Norway
(author)
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Jonsson, M. V.University of Bergen, Norway
(author)
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Harboe, E.Stavanger University Hospital, Norway
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Gøransson, L. G.Stavanger University Hospital, Norway
(author)
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Johnsen, S. J.Stavanger University Hospital, Norway
(author)
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Söderkvist, PeterLinköpings universitet,Cellbiologi,Hälsouniversitetet(Swepub:liu)petso43
(author)
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Eloranta, Maija-LeenaUppsala universitet,Institutionen för medicinska vetenskaper,Section of Rheumatology,Uppsala University(Swepub:uu)maelo020
(author)
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Alm, GunnarSwedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Inst för biomedicin och veterinär folkhälsovetenskap,Department of Biomedical Science and Veterinary Public Health,Swedish University of Agricultural Sciences, Uppsala(Swepub:slu)48141
(author)
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Baecklund, EvaUppsala universitet,Reumatologi,Section of Rheumatology,Uppsala University(Swepub:uu)evaba786
(author)
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Wahren-Herlenius, M.Karolinska Institutet,Karolinska Institutet, Stockholm
(author)
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Omdal, R.Stavanger University Hospital, Norway
(author)
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Rönnblom, LarsUppsala universitet,Institutionen för medicinska vetenskaper,Section of Rheumatology,Uppsala University(Swepub:uu)larsronn
(author)
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Jonsson, R.University of Bergen, Norway
(author)
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Syvänen, Ann-ChristineUppsala universitet,Molekylär medicin(Swepub:uu)anncsyva
(author)
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Uppsala universitetInstitutionen för medicinska vetenskaper
(creator_code:org_t)
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Sveriges lantbruksuniversitet
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In:Genes and Immunity: Springer Science and Business Media LLC12:2, s. 100-1091466-48791476-5470
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Nordmark, Gunnel
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Kristjansdottir, ...
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Theander, Elke
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Appel, S.
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Eriksson, Per
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Vasaitis, Lilian
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Kvarnström, M.
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Delaleu, N.
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Lundmark, Per
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Lundmark, Anders
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Sjöwall, Christo ...
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Brun, J. G.
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Jonsson, M. V.
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Harboe, E.
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Gøransson, L. G.
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Johnsen, S. J.
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Söderkvist, Pete ...
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Eloranta, Maija- ...
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Alm, Gunnar
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Baecklund, Eva
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Wahren-Herlenius ...
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Omdal, R.
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Rönnblom, Lars
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Jonsson, R.
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Syvänen, Ann-Chr ...
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Uppsala University
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Swedish University of Agricultural Sciences
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