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Higher Cathepsin B Levels in Plasma in Alzheimer's Disease Compared to Healthy Controls

Sundelöf, Johan (author)
Uppsala universitet,Geriatrik
Sundström, Johan (author)
Uppsala universitet,Institutionen för medicinska vetenskaper
Hansson, Oskar (author)
Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups
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Eriksdotter-Jönhagen, Maria (author)
Karolinska Institutet
Giedraitis, Vilmantas (author)
Uppsala universitet,Geriatrik
Larsson, Anders (author)
Uppsala universitet,Institutionen för medicinska vetenskaper,biologisk struktur och funktion
Degerman-Gunnarsson, Malin (author)
Uppsala universitet,Geriatrik
Ingelsson, Martin (author)
Uppsala universitet,Geriatrik
Minthon, Lennart (author)
Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups
Blennow, Kaj, 1958 (author)
Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
Kilander, Lena (author)
Uppsala universitet,Geriatrik
Basun, Hans (author)
Uppsala universitet,Geriatrik
Lannfelt, Lars (author)
Uppsala universitet,Geriatrik
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 (creator_code:org_t)
2010
2010
English.
In: Journal of Alzheimer's Disease. - 1387-2877 .- 1875-8908. ; 22:4, s. 1223-1230
Related links:
http://dx.doi.org/10...
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https://doi.org/10.3...
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  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Cathepsin B is suggested to be involved in amyloid-β (Aβ) processing and Alzheimer's disease (AD). Studies of cathepsin B levels in plasma and cerebrospinal fluid (CSF) have not been previously performed. We examined cathepsin B levels in plasma and CSF samples in persons with AD, mild cognitive impairment (MCI), and healthy controls in order to test the hypothesis that cathepsin B levels can discriminate persons with AD or MCI from healthy controls. Cathepsin B, Cystatin C, Aβ1-40 and Aβ1-42, total tau, phosphorylated tau, and albumin levels in plasma and CSF were analyzed by ELISA (Cathepsin B) turbidimetry (cystatin C), xMAP Luminex technology (Aβ1-40 and Aβ1-42 and tau), and Cobas C501 analyzer (albumin) in persons with AD (n=101), MCI (n=84), and healthy control subjects (n=28). Plasma cathepsin B levels were higher in persons with AD compared to healthy controls, both in unadjusted models and in multivariable models adjusting for age, gender, APOE genotype, cystatin C, and albumin levels: Odds ratio (OR) for AD per 1 SD of plasma cathepsin B; 2.04, 95% confidence interval (CI); 1.01-4.14, p= 0.05. There was no difference between diagnostic groups in cathepsin B levels in CSF: OR for AD per 1 SD of CSF cathepsin B; 0.93, 95% CI; 0.37-2.30, p= 0.87. Plasma cathepsin B levels were higher in persons with AD compared to healthy controls whereas there was no difference between diagnostic groups in cathepsin B levels in CSF. Further investigation of cathepsin B as a predictor of AD is warranted.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Neurologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Neurology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Psykiatri (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Psychiatry (hsv//eng)

Keyword

Alzheimer's disease
biomarkers
case control study
cathepsin B
cystatin C
epidemiology
risk factor
MEDICINE
MEDICIN
risk factor
epidemiology
cystatin C
cathepsin B
case control study
biomarkers
Alzheimer's disease

Publication and Content Type

ref (subject category)
art (subject category)

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