Search: onr:"swepub:oai:DiVA.org:uu-133800" >
Growth factor-antag...
Growth factor-antagonized rexinoid apoptosis involves permissive PPARgamma/RXR heterodimers to activate the intrinsic death pathway by NO.
-
Shankaranarayanan, Pattabhiraman (author)
-
Rossin, Aurélie (author)
-
Khanwalkar, Harshal (author)
-
show more...
-
Alvarez, Susana (author)
-
Alvarez, Rosana (author)
-
- Jacobson, Annica (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper
-
Nebbioso, Angela (author)
-
de Lera, Angel R (author)
-
Altucci, Lucia (author)
-
Gronemeyer, Hinrich (author)
-
show less...
-
(creator_code:org_t)
- Elsevier BV, 2009
- 2009
- English.
-
In: Cancer Cell. - : Elsevier BV. - 1535-6108 .- 1878-3686. ; 16:3, s. 220-31
- Related links:
-
http://www.cell.com/...
-
show more...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- Growth factor (GF) deprivation and/or blocking of cognate signaling can induce apoptosis and is the basis of several cancer treatment paradigms. We observed that RXR agonists (rexinoids) induce apoptosis of tumor cells when GF support is abrogated. This "rexinoid apoptosis" involves activation of both iNOS and eNOS by RXR-PPARgamma and results in production of apoptogenic NO. IGF/EGF-induced IGF receptor 1-mediated MAP kinase blocks rexinoid apoptosis by RXR phosphorylation. Combining rexinoids with the MAPK inhibitor U0126 induced apoptosis in human cancer cells in vitro and ex vivo and blocked xenograft growth in vivo. Our results suggest a regulatory mechanism in which GF signaling antagonizes RXR-PPARgamma-mediated default apoptosis to sustain cell life.
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database