onr:"swepub:oai:DiVA.org:uu-134101"
Search: onr:"swepub:oai:DiVA.org:uu-134101" > Neuronal collagen X...
- 1 of 1
- Previous record
- Next record
- To hitlist
Neuronal collagen XVII is localized to lipofuscin granules
- Seppanen, Allan (author)
- Miettinen, Riitta (author)
-
- Alafuzoff, Irina (author)
- Uppsala universitet,Institutionen för genetik och patologi,Alafuzoff
- (creator_code:org_t)
- 2010
- 2010
- English.
- In: NeuroReport. - 0959-4965 .- 1473-558X. ; 21:17, s. 1090-1094
- Journal article (peer-reviewed)
Abstract
Subject headings
Close
- We have earlier shown that collagen XVII is expressed by neurons in the human brain, although its exact intracellular location and function have remained unknown. In this study we have localized collagen XVII specifically to neuronal lipofuscin granules using electron microscopy in autopsy samples from the human brainstem. Our results show that collagen XVII expression is mainly confined to an ultrastructurally definable, specific type of lipofuscin granule. The function of neuronal collagen XVII remains unclear. However, as the functional significance of lipofuscin remains debated, the presence of collagen XVII in just some types of lipofuscin may be helpful in the process of exploring the variety of neuronal, age-related lipopigments, which are as yet defined operationally rather than functionally or structurally.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Klinisk laboratoriemedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Clinical Laboratory Medicine (hsv//eng)
Keyword
- brain
- collagen XVII
- lipofuscin
- Pathology
- Patologi
Publication and Content Type
- ref (subject category)
- art (subject category)
- 1 of 1
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Seppanen, Allan
- Miettinen, Riitt ...
- Alafuzoff, Irina
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
- and Clinical Medicin ...
- and Clinical Laborat ...
- Articles in the publication
- NeuroReport
- By the university
- Uppsala University
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
