A signal for an abuse liability for pregabalin-results from the Swedish spontaneous adverse drug reaction reporting system﻿

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MARC

Schwan, Sofie (author)

A signal for an abuse liability for pregabalin-results from the Swedish spontaneous adverse drug reaction reporting system

Article/chapterEnglish2010

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2010-06-19
Springer Science and Business Media LLC,2010
printrdacarrier

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LIBRIS-ID:oai:DiVA.org:uu-134979
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-134979URI
https://doi.org/10.1007/s00228-010-0853-yDOI
http://kipublications.ki.se/Default.aspx?queryparsed=id:121119618URI

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Language:English
Summary in:English

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SwePubSwePub

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Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

Notes

Pregabalin is a gamma-aminobutyric acid (GABA) analogue approved for the treatment of epilepsy, neuropathic pain and generalised anxiety disorder. As a GABA analogue, there has been some concern about an abuse liability. We aimed to investigate the possible abuse liability of pregabalin. By applying a Bayesian data-mining algorithm to reports of possible drug abuse or addiction in the Swedish national register of adverse drug reactions (SWEDIS), we calculated the information component (IC) for pregabalin and reports of abuse and addiction. Out of 198 reports indicative of abuse or addiction to any drug, 16 concerned pregabalin. The IC became significantly elevated in the fourth quarter of 2008, rising to 3.99 (95% confidence interval 3.21-4.59) at the end of 2009. Based on the signal from the present study, we conclude that pregabalin is likely to be associated with an abuse potential.

Subject headings and genre

Pregabalin
Abuse
Addiction
Adverse drug reaction
Data-mining
MEDICINE
MEDICIN

Added entries (persons, corporate bodies, meetings, titles ...)

Sundström, AndersKarolinska Institutet (author)
Stjernberg, ElisabetUppsala universitet,Klinisk farmakologi (author)
Hallberg, EbbaUppsala universitet,Klinisk farmakologi (author)
Hallberg, PärUppsala universitet,Klinisk farmakologi(Swepub:uu)pahal677 (author)
Karolinska InstitutetKlinisk farmakologi (creator_code:org_t)

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In:European Journal of Clinical Pharmacology: Springer Science and Business Media LLC66:9, s. 947-9530031-69701432-1041

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By the author/editor: Schwan, Sofie; Sundström, Ander ...; Stjernberg, Elis ...; Hallberg, Ebba; Hallberg, Pär

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