Search: onr:"swepub:oai:DiVA.org:uu-13502" >
An integrated gluco...
-
Jauslin, Petra MUppsala universitet,Avdelningen för farmakokinetik och läkemedelsterapi
(author)
An integrated glucose-insulin model to describe oral glucose tolerance test data in type 2 diabetics
- Article/chapterEnglish2007
Publisher, publication year, extent ...
-
2013-03-07
-
Wiley,2007
-
printrdacarrier
Numbers
-
LIBRIS-ID:oai:DiVA.org:uu-13502
-
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-13502URI
-
https://doi.org/10.1177/0091270007302168DOI
Supplementary language notes
-
Language:English
-
Summary in:English
Part of subdatabase
Classification
-
Subject category:ref swepub-contenttype
-
Subject category:art swepub-publicationtype
Notes
-
An integrated model for the glucose-insulin system describing oral glucose tolerance test data was developed, extending on a previously introduced model for intravenous glucose provocations. Model extensions comprised the description of glucose absorption by a chain of transit compartments with a mean transit time of 35 minutes, a bioavailability of 80%, and a representation of the incretin effect, expressed as a direct effect of the glucose absorption rate on insulin secretion. The ability of the model to predict the incretin effect was assessed by simulating the observed difference in insulin response following an oral glucose tolerance test compared with an isoglycemic glucose infusion mimicking an oral glucose tolerance test profile. The extension of the integrated glucose-insulin model to gain information from oral glucose tolerance test data considerably expands its range of applications because the oral glucose tolerance test is one of the most common glucose challenge experiments for assessing the efficacy of hypoglycemic agents in clinical drug development.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
-
Silber, Hanna EUppsala universitet,Avdelningen för farmakokinetik och läkemedelsterapi(Swepub:uu)hasil498
(author)
-
Frey, Nicolas
(author)
-
Gieschke, Ronald
(author)
-
Simonsson, Ulrika S HUppsala universitet,Avdelningen för farmakokinetik och läkemedelsterapi(Swepub:uu)usv12211
(author)
-
Jorga, Karin
(author)
-
Karlsson, Mats OUppsala universitet,Avdelningen för farmakokinetik och läkemedelsterapi(Swepub:uu)matskarl
(author)
-
Uppsala universitetAvdelningen för farmakokinetik och läkemedelsterapi
(creator_code:org_t)
Related titles
-
In:Journal of clinical pharmacology: Wiley47:10, s. 1244-12550091-27001552-4604
Internet link
Find in a library
To the university's database