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α-Melanocyte-stimul...
α-Melanocyte-stimulating hormone (α-MSH) reverses impairment of memory reconsolidation induced by interleukin-1 beta (IL-1 beta) hippocampal infusions
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Machado, Ivana (author)
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González, Patricia (author)
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- Schiöth, Helgi Birgir (author)
- Uppsala universitet,Institutionen för neurovetenskap,Functional Pharmacology/Funktionell Farmakologi
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Lasaga, Mercedes (author)
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Scimonelli, Teresa Nieves (author)
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(creator_code:org_t)
- Elsevier BV, 2010
- 2010
- English.
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In: Peptides. - : Elsevier BV. - 0196-9781 .- 1873-5169. ; 31:11, s. 2141-2144
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Interleukin-1 beta (IL-1β) significantly influences cognitive processes. Treatments which raise the level of IL-1β in the brain impair memory consolidation in contextual fear conditioning. However, the effect of IL-1β on memory reconsolidation has not yet been established. The melanocortin α-melanocyte-stimulating hormone (α-MSH) exerts potent anti-inflammatory actions by antagonizing the effect of proinflammatory cytokines. Five subtypes of melanocortin receptors (MC1R-MC5R) have been identified, of which MC3R and MC4R are predominant in the central nervous system. The present experiments show that the injection of IL-1β (5 ng/0.25 μl) in dorsal hippocampus up to 30 min after re-exposition to the context decreases freezing during the contextual fear test. Impairment of memory reconsolidation was reversed by treatment with α-MSH (0.05 μg/0.25 μl). Administration of the MC4 receptor antagonist HS014 (0.5 μg/0.25 μl) blocked the effect of α-MSH. These results suggest that IL-1β may influence memory reconsolidation and that activation of central MC4R could lead to improve cognitive performance.
Keyword
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
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