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Prr1 Coat Protein B...
Prr1 Coat Protein Binding to its Translational Operator
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- Persson, Magnus (author)
- Uppsala universitet,Strukturell molekylärbiologi
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- Tars, Kaspars (author)
- Latvian Biomedical Research and Study Center
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- Liljas, Lars (author)
- Uppsala universitet,Strukturell molekylärbiologi
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(creator_code:org_t)
- 2013
- 2013
- English.
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In: Acta Crystallographica Section D. - 0907-4449 .- 1399-0047. ; 69, s. 367-372
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- In small RNA bacteriophages, the genomic RNA binds to the coat proteins when the viral capsid assembles. This is achieved through sequence-specific interactions between a coat-protein dimer and an RNA stem-loop that includes the start codon for the replicase gene. The structure of virus-like particles of the small RNA phage PRR1 bound to an RNAsegment corresponding to this stem-loop has been solved and the binding was compared with the related, and better investigated, phage MS2. The overall conformation of the RNA is found to be similar and the residues that are involved in RNA binding in PRR1 are the same as in MS2. The arrangement of the nucleotide bases in the loop of the stem-loop is different, leading to a difference in the stacking at the conserved Tyr86, which is equivalent to Tyr85 in MS2.
Keyword
- PRR1
- virus
- coat protein
- RNA
Publication and Content Type
- ref (subject category)
- art (subject category)
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