Search: onr:"swepub:oai:DiVA.org:uu-135742" >
Spatiotemporal Dist...
Spatiotemporal Distribution and Function of N-Cadherin in Postnatal Schwann Cells : A Matter of Adhesion?
-
- Corell, Mikael (author)
- Uppsala universitet,Genetisk utvecklingsbiologi
-
- Wicher, Grzegorz (author)
- Uppsala universitet,Genetisk utvecklingsbiologi,Institutionen för farmaceutisk biovetenskap,Toxicology
-
- Limbach, Christoph (author)
- Uppsala universitet,Molekylär cellbiologi
-
show more...
-
- Kilimann, Manfred W. (author)
- Uppsala universitet,Molekylär cellbiologi
-
Colman, David R. (author)
-
- Svenningsen, Åsa Fex (author)
- Uppsala universitet,Genetisk utvecklingsbiologi
-
show less...
-
(creator_code:org_t)
- Wiley, 2010
- 2010
- English.
-
In: Journal of Neuroscience Research. - : Wiley. - 0360-4012 .- 1097-4547. ; 88:11, s. 2338-2349
- Related links:
-
https://urn.kb.se/re...
-
show more...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- During embryonic development of the peripheral nervous system (PNS), the adhesion molecule neuronal cadherin (N-cadherin) is expressed by Schwann cell precursors and associated with axonal growth cones. N-cadherin expression levels decrease as precursors differentiate into Schwann cells. In this study, we investigated the distribution of N-cadherin in the developing postnatal and adult rat peripheral nervous system. N-cadherin was found primarily in ensheathing glia throughout development, concentrated at neuron glial or glial glial contacts of the sciatic nerve, dorsal root ganglia (DRG), and myenteric plexi. In the sciatic nerve, N-cadherin decreases with age and progress of myelination. In adult animals, N-cadherin was found exclusively in nonmyelinating Schwann cells. The distribution of N-cadherin in developing E17 DRG primary cultures is similar to what was observed in vivo. Functional studies of N-cadherin in these cultures, using the antagonist peptide INPISGQ, show a disruption of the attachment between Schwann cells, but no interference in the initial or long-term contact between Schwann cells and axons. We suggest that N-cadherin acts primarily in the adhesion between glial cells during postnatal development. It may form adherents/junctions between nonmyelinating glia, which contribute to the stable tubular structure encapsulating thin caliber axons and thus stabilize the nerve structure as a whole.
Keyword
- PNS development
- nonmyelinating Schwann cells
- myelination
- enteric glia
- satellite cells
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database