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Cryptotomography : Reconstructing 3D Fourier Intensities from Randomly Oriented Single-Shot Diffraction Patterns
- Loh, N. D. (author)
- Bogan, M. J. (author)
- Elser, V. (author)
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- Barty, A. (author)
- Boutet, S. (author)
- Bajt, S. (author)
- Schulz, J. (author)
- Marchesini, S. (author)
- Schlichting, I. (author)
- Shoeman, R. L. (author)
- Lomb, L. (author)
- Frank, M. (author)
- Liang, M. (author)
- Chapman, H. N. (author)
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- (creator_code:org_t)
- 2010
- 2010
- English.
- In: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 104:22, s. 225501-1-225501-5
- Journal article (peer-reviewed)
Abstract
Subject headings
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- We reconstructed the 3D Fourier intensity distribution of monodisperse prolate nanoparticles using single-shot 2D coherent diffraction patterns collected at DESY's FLASH facility when a bright, coherent, ultrafast x-ray pulse intercepted individual particles of random, unmeasured orientations. This first experimental demonstration of cryptotomography extended the expansion-maximization-compression framework to accommodate unmeasured fluctuations in photon fluence and loss of data due to saturation or background scatter. This work is an important step towards realizing single-shot diffraction imaging of single biomolecules.
Subject headings
- NATURVETENSKAP -- Fysik (hsv//swe)
- NATURAL SCIENCES -- Physical Sciences (hsv//eng)
Keyword
- Physics
- Fysik
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- ref (subject category)
- art (subject category)
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- Loh, N. D.
- Bogan, M. J.
- Elser, V.
- Barty, A.
- Boutet, S.
- Bajt, S.
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- Hajdu, Janos
- Ekeberg, Tomas
- Maia, Filipe R. ...
- Schulz, J.
- Seibert, Marvin ...
- Iwan, Bianca
- Timneanu, Nicuso ...
- Marchesini, S.
- Schlichting, I.
- Shoeman, R. L.
- Lomb, L.
- Frank, M.
- Liang, M.
- Chapman, H. N.
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- Uppsala University
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