Search: onr:"swepub:oai:DiVA.org:uu-137727" >
Transcapillary exch...
Transcapillary exchange : role and importance of the interstitial fluid pressure and the extracellular matrix
- Article/chapterEnglish2010
Publisher, publication year, extent ...
-
2010-05-13
-
Oxford University Press (OUP),2010
-
printrdacarrier
Numbers
-
LIBRIS-ID:oai:DiVA.org:uu-137727
-
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-137727URI
-
https://doi.org/10.1093/cvr/cvq143DOI
Supplementary language notes
-
Language:English
-
Summary in:English
Part of subdatabase
Classification
-
Subject category:ref swepub-contenttype
-
Subject category:for swepub-publicationtype
Notes
-
This review will summarize current knowledge on the role of the extracellular matrix (ECM) in general and on the interstitial fluid pressure (P-if) in particular with regard to their importance in transcapillary exchange. The fluid volume in the interstitial space is normally regulated within narrow limits by automatic re-adjustment of the interstitial hydrostatic and colloid osmotic pressures in response to perturbations in capillary filtration and by the lymphatics. Contrary to this commonly accepted view, P-if can become an active force and create a fluid flux across the capillaries in several inflammatory reactions and trauma situations rather than limit the changes occurring. The molecular mechanisms involved in the lowering of P-if include the release of cellular tension exerted on the collagen and microfibril networks in the connective tissue via the collagen-binding beta(1)-integrins, thereby allowing the glycosaminoglycan ground substance, which is normally underhydrated, to expand and take up fluid. Several growth factors and cytokines, including the platelet-derived growth factor BB, are able to reverse a lowering of P-if and restore the normal compaction of the ECM. The magnitude of the lowering of P-if varies with the inflammatory response. In several inflammatory reactions, a lowering of P-if to -5 to -10 mmHg is seen, which will increase capillary filtration by 10-20 times since the normal capillary filtration pressure is usually 0.5-1 mmHg (skin and skeletal muscle). Unless this lowering of P-if is taken into account, the enhanced solute flux resulting from an inflammatory response will be ascribed to an increased capillary permeability.
Subject headings and genre
-
Connective tissue
-
beta-Integrin receptors
-
Glycosaminoglycans
-
Inflammation
-
MEDICINE
-
MEDICIN
Added entries (persons, corporate bodies, meetings, titles ...)
-
Rubin, KristoferUppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi(Swepub:uu)krisrubi
(author)
-
Uppsala universitetInstitutionen för medicinsk biokemi och mikrobiologi
(creator_code:org_t)
Related titles
-
In:Cardiovascular Research: Oxford University Press (OUP)87:2, s. 211-2170008-63631755-3245
Internet link
Find in a library
To the university's database