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In vitro and in viv...
In vitro and in vivo evaluation of an injectable premixed calcium phosphate cement : cell viability and immunological response from rat
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- Åberg, Jonas, 1982- (author)
- Gothenburg University,Göteborgs universitet,Uppsala universitet,Tillämpad materialvetenskap,Materials in Medicine,Institutionen för kliniska vetenskaper, Avdelningen för biomaterialvetenskap,Institute of Clinical Sciences, Department of Biomaterials
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- Barreto Henriksson, Helena (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för ortopedi,Institute of Clinical Sciences, Department of Orthopaedics
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- Engqvist, Håkan (author)
- Gothenburg University,Göteborgs universitet,Uppsala universitet,Tillämpad materialvetenskap,Materials in Medicine,Institutionen för kliniska vetenskaper, Avdelningen för biomaterialvetenskap,Institute of Clinical Sciences, Department of Biomaterials
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- Palmquist, Anders, 1977 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för biomaterialvetenskap,Institute of Clinical Sciences, Department of Biomaterials
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- Lindahl, Anders, 1954 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för klinisk kemi och transfusionsmedicin,Institute of Biomedicine, Department of Clinical Chemistry and Transfusion Medicine
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- Thomsen, Peter, 1953 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för biomaterialvetenskap,Institute of Clinical Sciences, Department of Biomaterials
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- Brisby, Helena, 1965 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för ortopedi,Institute of Clinical Sciences, Department of Orthopaedics
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(creator_code:org_t)
- 2010
- 2010
- English.
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In: International Journal of Nano and Biomaterials. - 1752-8941. ; 3:3, s. 203-221
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https://doi.org/10.1...
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Abstract
Subject headings
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- By using premixed calcium phosphate cement (CPC) the handling properties of the cement are drastically improved, which is a challenge for traditional injectable CPC. In this article, a premixed acidic CPC has been compared to a conventional water mixed brushite cement to evaluate whether the premixed concept affects the biological response. The cements were evaluated regarding the pH-variation in simulated body fluid (SBF). Further, the biocompatibility of the cement with human mesenchymal stem cells (MSC) was studied in vitro and eventual inflammation properties studied in vivo, after subcutaneous material injections in rats. A larger pH decrease was seen for the conventional cement than the premixed cement in SBF. For both materials, > 90% of the MSC remained alive in vitro. No systemic or macroscopic inflammation was detected, only a mild microscopic inflammation was detected around both materials. In addition to the handling benefit of premixed cements compared to conventional water mixed CPC, the premixed CPC in the present study demonstrated high and in comparison to conventional CPC comparable biocompability, both in vitro and in vivo.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi -- Biomaterialvetenskap (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology -- Biomaterials Science (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Keyword
- premixed
- calcium phosphate cement
- in vitro
- in vivo
- TECHNOLOGY
- TEKNIKVETENSKAP
- Materialvetenskap
- Materials Science
- injectable calcium phosphare cement
- mesenchymal stem cells
- biocompability
- immunological response
Publication and Content Type
- ref (subject category)
- art (subject category)
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Åberg, Jonas, 19 ...
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Barreto Henrikss ...
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Engqvist, Håkan
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Palmquist, Ander ...
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Lindahl, Anders, ...
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Thomsen, Peter, ...
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Brisby, Helena, ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Medical Biotechn ...
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and Biomaterials Sci ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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International Jo ...
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International Jo ...
- By the university
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Uppsala University
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University of Gothenburg