Search: onr:"swepub:oai:DiVA.org:uu-138776" > Antigen processing ...
Fältnamn | Indikatorer | Metadata |
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000 | 03352naa a2200637 4500 | |
001 | oai:DiVA.org:uu-138776 | |
003 | SwePub | |
008 | 101220s2010 | |||||||||||000 ||eng| | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1387762 URI |
024 | 7 | a https://doi.org/10.1038/ni.19742 DOI |
040 | a (SwePub)uu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Kessler, Jan H.4 aut |
245 | 1 0 | a Antigen processing by nardilysin and thimet oligopeptidase generates cytotoxic T cell epitopes |
264 | c 2010-12-12 | |
264 | 1 | b Springer Science and Business Media LLC,c 2010 |
338 | a print2 rdacarrier | |
500 | a Peter A van Veelen, Ferry Ossendorp & Cornelis J M Melief contributed equally to this work. | |
520 | a Cytotoxic T lymphocytes (CTLs) recognize peptides presented by HLA class I molecules on the cell surface. The C terminus of these CTL epitopes is considered to be produced by the proteasome. Here we demonstrate that the cytosolic endopeptidases nardilysin and thimet oligopeptidase (TOP) complemented proteasome activity. Nardilysin and TOP were required, either together or alone, for the generation of a tumor-specific CTL epitope from PRAME, an immunodominant CTL epitope from Epstein-Barr virus protein EBNA3C, and a clinically important epitope from the melanoma protein MART-1. TOP functioned as C-terminal trimming peptidase in antigen processing, and nardilysin contributed to both the C-terminal and N-terminal generation of CTL epitopes. By broadening the antigenic peptide repertoire, nardilysin and TOP strengthen the immune defense against intracellular pathogens and cancer. | |
653 | a MEDICINE | |
653 | a MEDICIN | |
700 | 1 | a Khan, Selina4 aut |
700 | 1 | a Seifert, Ulrike4 aut |
700 | 1 | a Le Gall, Sylvie4 aut |
700 | 1 | a Chow, K .Martin4 aut |
700 | 1 | a Paschen, Annette4 aut |
700 | 1 | a Bres-Vloemans, Sandra A.4 aut |
700 | 1 | a de Ru, Arnoud4 aut |
700 | 1 | a van Montfoort, Nadine4 aut |
700 | 1 | a Franken, Kees L.M.C.4 aut |
700 | 1 | a Benckhuijsen, Willemien E.4 aut |
700 | 1 | a Brooks, Jill M.4 aut |
700 | 1 | a van Hall, Thorbald4 aut |
700 | 1 | a Ray, Kallol4 aut |
700 | 1 | a Mulder, Arend4 aut |
700 | 1 | a Doxiadis, Ilias I. N.4 aut |
700 | 1 | a van Swieten, Paul F.4 aut |
700 | 1 | a Overkleeft, Hermen S.4 aut |
700 | 1 | a Prat, Annik4 aut |
700 | 1 | a Tomkinson, Birgittau Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi4 aut0 (Swepub:uu)bto18995 |
700 | 1 | a Neefjes, Jacques4 aut |
700 | 1 | a Kloetzel, Peter M.4 aut |
700 | 1 | a Rodgers, David W.4 aut |
700 | 1 | a Hersh, Louis B.4 aut |
700 | 1 | a Drijfhout, Jan W.4 aut |
700 | 1 | a van Veelen, Peter A.4 aut |
700 | 1 | a Ossendorp, Ferry4 aut |
700 | 1 | a Melief, Cornelis J. M.4 aut |
710 | 2 | a Uppsala universitetb Institutionen för medicinsk biokemi och mikrobiologi4 org |
773 | 0 | t Nature Immunologyd : Springer Science and Business Media LLCg 12:1, s. 45-53q 12:1<45-53x 1529-2908x 1529-2916 |
856 | 4 | u https://scholarlypublications.universiteitleiden.nl/access/item%3A3210300/view |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-138776 |
856 | 4 8 | u https://doi.org/10.1038/ni.1974 |
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