Search: onr:"swepub:oai:DiVA.org:uu-139261" >
A genome-wide assoc...
A genome-wide association study of Hodgkin's lymphoma identifies new susceptibility loci at 2p16.1 (REL), 8q24.21 and 10p14 (GATA3)
-
Enciso-Mora, Victor (author)
-
Broderick, Peter (author)
-
Ma, Yussanne (author)
-
show more...
-
Jarrett, Ruth F. (author)
-
- Hjalgrim, Henrik (author)
- Karolinska Institutet
-
- Hemminki, Kari (author)
- Lund University,Lunds universitet,Allmänmedicin och klinisk epidemiologi,Forskargrupper vid Lunds universitet,Family Medicine and Clinical Epidemiology,Lund University Research Groups
-
van den Berg, Anke (author)
-
Olver, Bianca (author)
-
Lloyd, Amy (author)
-
Dobbins, Sara E. (author)
-
Lightfoot, Tracy (author)
-
van Leeuwen, Flora E. (author)
-
Foersti, Asta (author)
-
Diepstra, Arjan (author)
-
Broeks, Annegien (author)
-
Vijayakrishnan, Jayaram (author)
-
Shield, Lesley (author)
-
Lake, Annette (author)
-
Montgomery, Dorothy (author)
-
Roman, Eve (author)
-
Engert, Andreas (author)
-
von Strandmann, Elke Pogge (author)
-
Reiners, Katrin S. (author)
-
Nolte, Ilja M. (author)
-
- Smedby, Karin E. (author)
- Karolinska Institutet
-
Adami, Hans-Olov (author)
-
Russell, Nicola S. (author)
-
- Glimelius, Bengt (author)
- Karolinska Institutet,Uppsala universitet,Enheten för onkologi
-
Hamilton-Dutoit, Stephen (author)
-
de Bruin, Marieke (author)
-
Ryder, Lars P. (author)
-
- Molin, Daniel (author)
- Uppsala universitet,Enheten för onkologi
-
Sorensen, Karina Meden (author)
-
Chang, Ellen T. (author)
-
Taylor, Malcolm (author)
-
Cooke, Rosie (author)
-
Hofstra, Robert (author)
-
Westers, Helga (author)
-
van Wezel, Tom (author)
-
van Eijk, Ronald (author)
-
Ashworth, Alan (author)
-
Rostgaard, Klaus (author)
-
Melbye, Mads (author)
-
Swerdlow, Anthony J. (author)
-
Houlston, Richard S. (author)
-
show less...
-
(creator_code:org_t)
- 2010-10-31
- 2010
- English.
-
In: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 42:12, s. 1126-1130
- Related links:
-
https://europepmc.or...
-
show more...
-
http://dx.doi.org/10...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
https://lup.lub.lu.s...
-
http://kipublication...
-
show less...
Abstract
Subject headings
Close
- To identify susceptibility loci for classical Hodgkin's lymphoma (cHL), we conducted a genome-wide association study of 589 individuals with cHL (cases) and 5,199 controls with validation in four independent samples totaling 2,057 cases and 3,416 controls. We identified three new susceptibility loci at 2p16.1 (rs1432295, REL, odds ratio (OR) = 1.22, combined P = 1.91 × 10−8), 8q24.21 (rs2019960, PVT1, OR = 1.33, combined P = 1.26 × 10−13) and 10p14 (rs501764, GATA3, OR = 1.25, combined P = 7.05 × 10−8). Furthermore, we confirmed the role of the major histocompatibility complex in disease etiology by revealing a strong human leukocyte antigen (HLA) association (rs6903608, OR = 1.70, combined P = 2.84 × 10−50). These data provide new insight into the pathogenesis of cHL.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
Keyword
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Enciso-Mora, Vic ...
-
Broderick, Peter
-
Ma, Yussanne
-
Jarrett, Ruth F.
-
Hjalgrim, Henrik
-
Hemminki, Kari
-
show more...
-
van den Berg, An ...
-
Olver, Bianca
-
Lloyd, Amy
-
Dobbins, Sara E.
-
Lightfoot, Tracy
-
van Leeuwen, Flo ...
-
Foersti, Asta
-
Diepstra, Arjan
-
Broeks, Annegien
-
Vijayakrishnan, ...
-
Shield, Lesley
-
Lake, Annette
-
Montgomery, Doro ...
-
Roman, Eve
-
Engert, Andreas
-
von Strandmann, ...
-
Reiners, Katrin ...
-
Nolte, Ilja M.
-
Smedby, Karin E.
-
Adami, Hans-Olov
-
Russell, Nicola ...
-
Glimelius, Bengt
-
Hamilton-Dutoit, ...
-
de Bruin, Mariek ...
-
Ryder, Lars P.
-
Molin, Daniel
-
Sorensen, Karina ...
-
Chang, Ellen T.
-
Taylor, Malcolm
-
Cooke, Rosie
-
Hofstra, Robert
-
Westers, Helga
-
van Wezel, Tom
-
van Eijk, Ronald
-
Ashworth, Alan
-
Rostgaard, Klaus
-
Melbye, Mads
-
Swerdlow, Anthon ...
-
Houlston, Richar ...
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Health Sciences
-
and Public Health Gl ...
- Articles in the publication
-
Nature Genetics
- By the university
-
Uppsala University
-
Lund University
-
Karolinska Institutet