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Hospitalization for...
Hospitalization for osteoarthritis and prostate cancer specific mortality among Swedish men with prostate cancer
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- Fang, Fang (author)
- Karolinska Institutet
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- Valdimarsdottir, Unnur (author)
- Karolinska Institutet
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- Mucci, Lorelei (author)
- Centre for Public Health Sciences, University of Iceland, Reykjavik, Iceland; Department of Epidemiology, Harvard School of Public Health, Boston, USA; Channing Laboratory, Brigham and Women’s Hospital, Harvard Medical School, Boston, USA
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- Sparén, Par (author)
- Karolinska Institutet
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- Ye, Weimin (author)
- Karolinska Institutet
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- Fall, Katja, 1971- (author)
- Uppsala universitet,Institutionen för genetik och patologi,Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; Centre for Public Health Sciences, University of Iceland, Reykjavik, Iceland; Department of Genetics and Pathology, Uppsala University, Uppsala, Sweden
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(creator_code:org_t)
- Oxon, United Kingdom : Elsevier BV, 2010
- 2010
- English.
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In: Cancer Epidemiology. - Oxon, United Kingdom : Elsevier BV. - 1877-7821 .- 1877-783X. ; 34:5, s. 644-647
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Purpose: To examine the potential role of nonsteroidal anti-inflammatory drugs (NSAIDs) use on prostate cancer (PCa) specific mortality. Methods: We studied the association between hospitalization for osteoarthritis prior to PCa diagnosis, as a surrogate for heavy use of NSAIDs, and PCa specific mortality in a large population of PCa patients in Sweden in 1980-2004. Results: Hospitalization for osteoarthritis before PCa diagnosis was associated to a lower PCa specific mortality (hazard ratio [HR], 0.92; 95% confidence interval [CI], 0.88-0.96), but not to the risk of death from other causes (HR, 1.03; 95% Cl, 0.99-1.08). The association was stronger among younger patients and patients diagnosed in earlier calendar years. Conclusions: Our data demonstrate a modestly decreased PCa specific mortality among PCa patients with hospitalization for osteoarthritis prior to PCa diagnosis, compared to those without such experience. This finding lends support to the hypothesis that NSAIDs use may influence PCa progression.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- NSAIDs
- Osteoarthritis
- Prostate cancer specific mortality
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
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