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Relations of biomar...
Relations of biomarkers of extracellular matrix remodeling to incident cardiovascular events and mortality
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Velagaleti, Raghava S. (author)
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Gona, Philimon (author)
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- Sundström, Johan (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Uppsala kliniska forskningscentrum (UCR)
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Larson, Martin G. (author)
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Siwik, Deborah (author)
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Colucci, Wilson S. (author)
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Benjamin, Emelia J. (author)
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Vasan, Ramachandran S. (author)
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(creator_code:org_t)
- 2010
- 2010
- English.
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In: Arteriosclerosis, Thrombosis and Vascular Biology. - 1079-5642 .- 1524-4636. ; 30:11, s. 2283-2288
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- OBJECTIVE-: To evaluate if biomarkers reflecting left ventricular/vascular extracellular matrix remodeling are associated with cardiovascular disease (CVD) and death in the community. METHODS AND RESULTS-: In 922 Framingham Study participants (mean age, 58 years; 56% women), we related circulating concentrations of matrix metalloproteinase-9 (binary variable: detectable versus undetectable), log of tissue inhibitor of matrix metalloproteinase-1, and log of procollagen type III aminoterminal peptide (PIIINP) to incident CVD and death. On follow-up (mean, 9.9 years), 51 deaths and 81 CVD events occurred. Each SD increment of log of tissue inhibitor of matrix metalloproteinase-1 and log-PIIINP was associated with multivariable-adjusted hazards ratios of 1.72 (95% CI, 1.30 to 2.27) and 1.47 (95% CI, 1.11 to 1.96), respectively, for mortality risk. Log-PIIINP concentrations were also associated with CVD risk (hazard ratio [95% CI] per SD, 1.35 [1.05 to 1.74]). Death and CVD incidence rates were 2-fold higher in participants with both biomarkers higher than the median (corresponding hazard ratio [95% CI], 2.78 [1.43 to 5.40] and 1.77 [1.04 to 3.03], respectively) compared with those with either or both less than the median. The inclusion of both biomarkers improved the C-statistic (for predicting mortality) from 0.78 to 0.82 (P=0.03). Matrix metalloproteinase-9 was unrelated to either outcome. CONCLUSION-: Higher circulating tissue inhibitor of matrix metalloproteinase-1 and PIIINP concentrations are associated with mortality, and higher PIIINP is associated with incident CVD, in the community.
Keyword
- cardiovascular disease
- extracellular matrix
- left ventricle
- matrix metalloproteinase-9
- procollagen type III amino-terminal peptide
- remodeling
- tissue inhibitor of matrix metalloproteinase-1
- MEDICINE
- MEDICIN
- Internmedicin
- Internal Medicine
Publication and Content Type
- ref (subject category)
- art (subject category)
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