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  • Ahlgren, Kerstin M.Uppsala universitet,Institutionen för medicinska vetenskaper,Autoimmuna sjukdomar, Autoimmunity (author)

Increased IL-17A secretion in response to Candida albicans in autoimmune polyendocrine syndrome type 1 and its animal model

  • Article/chapterEnglish2011

Publisher, publication year, extent ...

  • 2010-12-03
  • Wiley,2011
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-140180
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-140180URI
  • https://doi.org/10.1002/eji.200939883DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:122002118URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Autoimmune polyendocrine syndrome type 1 (APS-1) is a multiorgan autoimmune disease caused by mutations in the autoimmune regulator (AIRE) gene. Chronic mucocutaneous candidiasis, hypoparathyroidism and adrenal failure are hallmarks of the disease. The critical mechanisms causing chronic mucocutaneous candidiasis in APS-1 patients have not been identified although autoantibodies to cytokines are implicated in the pathogenesis. To investigate whether the Th reactivity to Candida albicans (C. albicans) and other stimuli was altered, we isolated PBMC from APS-1 patients and matched healthy controls. The Th17 pathway was upregulated in response to C. albicans in APS-1 patients, whereas the IL-22 secretion was reduced. Autoantibodies against IL-22, IL-17A and IL-17F were detected in sera from APS-1 patients by immunoprecipitation. In addition, Aire-deficient (Aire(0/0) ) mice were much more susceptible than Aire(+/+) mice to mucosal candidiasis and C. albicans-induced Th17- and Th1-cell responses were increased in Aire(0/0) mice. Thus an excessive IL-17A reactivity towards C. albicans was observed in APS-1 patients and Aire(0/0) mice.

Subject headings and genre

  • Autoimmunity
  • Cytokines
  • Fungal
  • T cells
  • MEDICINE
  • MEDICIN

Added entries (persons, corporate bodies, meetings, titles ...)

  • Moretti, Silvia (author)
  • Lundgren, Brita ArdesjöUppsala universitet,Institutionen för medicinska vetenskaper,Autoimmuna sjukdomar, Autoimmunity (author)
  • Karlsson, IuliaUppsala universitet,Institutionen för medicinska vetenskaper (author)
  • Åhlin, ErikUppsala universitet,Klinisk immunologi,Rönnelid(Swepub:uu)eriah588 (author)
  • Norling, AnnaUppsala universitet,Institutionen för medicinska vetenskaper,Lobell/Kämpe(Swepub:uu)annor622 (author)
  • Hallgren, ÅsaUppsala universitet,Institutionen för medicinska vetenskaper,Autoimmuna sjukdomar, Autoimmunity (author)
  • Perheentupa, Jaakko (author)
  • Gustafsson, JanUppsala universitet,Pediatrik,Barnendokrinologisk forskning/Gustafsson(Swepub:uu)jangfs (author)
  • Rorsman, FredrikUppsala universitet,Institutionen för medicinska vetenskaper,Rorsman(Swepub:uu)fredrikr (author)
  • Crewther, Pauline E. (author)
  • Rönnelid, JohanUppsala universitet,Klinisk immunologi,Rönnelid(Swepub:uu)joharonn (author)
  • Bensing, SophieKarolinska Institutet,Uppsala universitet,Institutionen för medicinska vetenskaper,Autoimmuna sjukdomar, Autoimmunity(Swepub:uu)sopbe271 (author)
  • Scott, Hamish S. (author)
  • Kämpe, Olle,1956-Uppsala universitet,Institutionen för medicinska vetenskaper,Autoimmuna sjukdomar, Autoimmunity(Swepub:uu)ollekamp (author)
  • Romani, Luigina (author)
  • Lobell, AnnaUppsala universitet,Institutionen för medicinska vetenskaper,Lobell/Autoimmuna sjukdomar, Autoimmunity(Swepub:uu)anlob030 (author)
  • Uppsala universitetInstitutionen för medicinska vetenskaper (creator_code:org_t)

Related titles

  • In:European Journal of Immunology: Wiley41:1, s. 235-2450014-29801521-4141

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