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Antimicrobial and a...
Antimicrobial and antineoplastic activities of Agelasine analogs modified in the purine 2-position
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- Roggen, Heidi (author)
- Department of Chemistry, Oslo University
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- Charnock, Colin (author)
- Faculty of Health Sciences, Oslo University
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- Burman, Robert (author)
- Uppsala universitet,Avdelningen för farmakognosi
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- Felth, Jenny (author)
- Uppsala universitet,Avdelningen för farmakognosi
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- Larsson, Rolf (author)
- Uppsala universitet,Klinisk farmakologi,Cancer Pharmacology and Informatics/Rolf Larsson
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- Bohlin, Lars, 1948- (author)
- Uppsala universitet,Avdelningen för farmakognosi
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- Gundersen, Lise-Lotte (author)
- Department of Chemistry, Oslo University
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(creator_code:org_t)
- 2010-11-25
- 2011
- English.
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In: Archiv der Pharmazie. - : Wiley. - 0365-6233 .- 1521-4184. ; 344:1, s. 50-55
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Agelasines are 7,9-dialkylpurinium salts found in marine sponges (Agelas sp.), which display a variety of antimicrobial and cytotoxic effects. We have synthesized simplified agelasine analogs modified in the purine 2-position and examined their antimicrobial and anticancer activities. The compounds were screened against Staphylococcus aureus, Escherichia coli, Mycobacterium tuberculosis, Candida krusei, and Candida albicans, protozoa causing tropical diseases (Plasmodium falciparum, Leishmania infantum, Trypanosoma cruzi, and Trypanosoma brucei), a panel of human cancer cell lines (U-937 GTB, RPMI 8226/s, CEM/s, and ACHN) as well as VERO and/or MRC-5 cells. The results indicate that the introduction of a methyl group in the purine 2-position is beneficial for antimycobacterial and antiprotozoal activity, and that amino groups may enhance activity against several cancer cell lines.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmaceutiska vetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmaceutical Sciences (hsv//eng)
Keyword
- Agelasine
- Antibacterial activity
- Anticancer acivitity
- Antifungal activity
- Antiprotozoal activity
- PHARMACY
- FARMACI
Publication and Content Type
- ref (subject category)
- art (subject category)
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