onr:"swepub:oai:DiVA.org:uu-141348"
Search: onr:"swepub:oai:DiVA.org:uu-141348" > Effects of dietary ...
- 1 of 1
- Previous record
- Next record
- To hitlist
Effects of dietary fat modification on insulin sensitivity and on other risk factors of the metabolic syndrome-LIPGENE : a European randomized dietary intervention study
- Tierney, A C (author)
- McMonagle, J (author)
- Shaw, D I (author)
- show more...
- Gulseth, H L (author)
- Helal, O (author)
- Saris, W H M (author)
- Paniagua, J A (author)
- Gołąbek-Leszczyñska, I (author)
- Defoort, C (author)
- Williams, C M (author)
- Dembinska-Kiec, A (author)
- López-Miranda, J (author)
- Blaak, E E (author)
- Drevon, C A (author)
- Gibney, M J (author)
- Lovegrove, J A (author)
- Roche, H M (author)
- show less...
- (creator_code:org_t)
- 2010-10-12
- 2011
- English.
- In: International Journal of Obesity. - : Springer Science and Business Media LLC. - 0307-0565 .- 1476-5497. ; 35:6, s. 800-809
- Journal article (peer-reviewed)
Abstract
Subject headings
Close
- Background:Excessive energy intake and obesity lead to the metabolic syndrome (MetS). Dietary saturated fatty acids (SFAs) may be particularly detrimental on insulin sensitivity (SI) and on other components of the MetS.Objective:This study determined the relative efficacy of reducing dietary SFA, by isoenergetic alteration of the quality and quantity of dietary fat, on risk factors associated with MetS.Design:A free-living, single-blinded dietary intervention study.Subjects and Methods:MetS subjects (n=417) from eight European countries completed the randomized dietary intervention study with four isoenergetic diets distinct in fat quantity and quality: high-SFA; high-monounsaturated fatty acids and two low-fat, high-complex carbohydrate (LFHCC) diets, supplemented with long chain n-3 polyunsaturated fatty acids (LC n-3 PUFAs) (1.2 g per day) or placebo for 12 weeks. SI estimated from an intravenous glucose tolerance test (IVGTT) was the primary outcome measure. Lipid and inflammatory markers associated with MetS were also determined.Results:In weight-stable subjects, reducing dietary SFA intake had no effect on SI, total and low-density lipoprotein cholesterol concentration, inflammation or blood pressure in the entire cohort. The LFHCC n-3 PUFA diet reduced plasma triacylglycerol (TAG) and non-esterified fatty acid concentrations (P<0.01), particularly in men.Conclusion:There was no effect of reducing SFA on SI in weight-stable obese MetS subjects. LC n-3 PUFA supplementation, in association with a low-fat diet, improved TAG-related MetS risk profiles.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
Keyword
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
- International Journal of Obesity (Search for host publication in LIBRIS)
To the university's database
- 1 of 1
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Tierney, A C
- McMonagle, J
- Shaw, D I
- Gulseth, H L
- Helal, O
- Saris, W H M
- show more...
- Paniagua, J A
- Gołąbek-Leszczyñ ...
- Defoort, C
- Williams, C M
- Karsltröm, Brita
- Vessby, Bengt
- Dembinska-Kiec, ...
- López-Miranda, J
- Blaak, E E
- Drevon, C A
- Gibney, M J
- Lovegrove, J A
- Roche, H M
- show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
- and Health Sciences
- and Nutrition and Di ...
- Articles in the publication
- International Jo ...
- By the university
- Uppsala University
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
