Search: onr:"swepub:oai:DiVA.org:uu-141429" >
Two-year follow-up ...
Two-year follow-up of amyloid deposition in patients with Alzheimer's disease
-
Engler, Henry (author)
-
- Forsberg, Anton (author)
- Karolinska Institutet
-
- Almkvist, Ove (author)
- Stockholms universitet,Karolinska Institutet,Psykologiska institutionen
-
show more...
-
- Blomquist, Gunnar (author)
- Uppsala universitet,Institutionen för onkologi, radiologi och klinisk immunologi
-
Larsson, Emma (author)
-
- Savitcheva, Irina (author)
- Uppsala universitet
-
Wall, Anders (author)
-
Ringheim, Anna (author)
-
- Långström, Bengt (author)
- Uppsala universitet,Institutionen för biokemi och organisk kemi
-
Nordberg, Agneta (author)
-
show less...
-
(creator_code:org_t)
- 2006-09-29
- 2006
- English.
-
In: Brain. - : Oxford University Press (OUP). - 0006-8950 .- 1460-2156. ; 129:Pt 11, s. 2856-2866
- Related links:
-
https://academic.oup...
-
show more...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
http://kipublication...
-
https://urn.kb.se/re...
-
show less...
Abstract
Subject headings
Close
- Beta amyloid is one of the major histopathological hallmarks of Alzheimer's disease. We recently reported in vivo imaging of amyloid in 16 Alzheimer patients, using the PET ligand N-methyl[11C]2-(4'-methylaminophenyl)-6-hydroxy-benzothiazole (PIB). In the present study we rescanned these 16 Alzheimer patients after 2.0 +/- 0.5 years and have described the interval change in amyloid deposition and regional cerebral metabolic rate for glucose (rCMRGlc) at follow-up. Sixteen patients with Alzheimer's disease were re-examined by means of PET, using PIB and 2-[18F]fluoro-2-deoxy-d-glucose (FDG) after 2.0 +/- 0.5 years. The patients were all on cholinesterase inhibitor treatment and five also on treatment with the N-methyl-d-aspartate (NMDA) antagonist memantine. In order to estimate the accuracy of the PET PIB measurements, four additional Alzheimer patients underwent repeated examinations with PIB within 20 days (test-retest). Relative PIB retention in cortical regions differed by 3-7% in the test-retest study. No significant difference in PIB retention was observed between baseline and follow-up while a significant (P < 0.01) 20% decrease in rCMRGlc was observed in cortical brain regions. A significant negative correlation between rCMRGlc and PIB retention was observed in the parietal cortex in the Alzheimer patients at follow-up (r = 0.67, P = 0.009). A non-significant decline in Mini-Mental State Examination (MMSE) score from 24.3 +/- 3.7 (mean +/- standard deviation) to 22.7 +/- 6.1 was measured at follow-up. Five of the Alzheimer patients showed a significant decline in MMSE score of >3 (21.4 +/- 3.5 to 15.6 +/- 3.9, P < 0.01) (AD-progressive) while the rest of the patients were cognitively more stable (MMSE score = 25.6 +/- 3.1 to 25.9 +/- 3.7) (AD-stable) compared with baseline. A positive correlation (P = 0.001) was observed in the parietal cortex between Rey Auditory Verbal Learning (RAVL) test score and rCMRGlc at follow-up while a negative correlation (P = 0.018) was observed between RAVL test and PIB retention in the parietal at follow-up. Relatively stable PIB retention after 2 years of follow-up in patients with mild Alzheimer's disease suggests that amyloid deposition in the brain reaches a plateau by the early clinical stages of Alzheimer's disease and therefore may precede a decline in rCMRGlc and cognition. It appears that anti-amyloid therapies will need to induce a significant decrease in amyloid load in order for PIB PET images to detect a drug effect in Alzheimer patients. FDG imaging may be able to detect a stabilization of cerebral metabolism caused by therapy administered to patients with a clinical diagnosis of Alzheimer's disease.
Subject headings
- SAMHÄLLSVETENSKAP -- Psykologi (hsv//swe)
- SOCIAL SCIENCES -- Psychology (hsv//eng)
Keyword
- Alzheimer's disease
- amyloid
- PET
- PIB
- FDG
- follow-up
- MEDICINE
- MEDICIN
- Psychology
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
-
Brain
(Search for host publication in LIBRIS)
To the university's database
- By the author/editor
-
Engler, Henry
-
Forsberg, Anton
-
Almkvist, Ove
-
Blomquist, Gunna ...
-
Larsson, Emma
-
Savitcheva, Irin ...
-
show more...
-
Wall, Anders
-
Ringheim, Anna
-
Långström, Bengt
-
Nordberg, Agneta
-
show less...
- About the subject
-
- SOCIAL SCIENCES
-
SOCIAL SCIENCES
-
and Psychology
- Articles in the publication
-
Brain
- By the university
-
Uppsala University
-
Karolinska Institutet
-
Stockholm University