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Consensus Paper of ...
Consensus Paper of the WFSBP Task Force on Biological Markers of Dementia : The role of CSF and blood analysis in the early and differential diagnosis of dementia
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Wiltfang, J. (author)
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Lewczuk, P. (author)
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Riederer, P. (author)
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Gruenblatt, E. (author)
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Hock, C. (author)
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Scheltens, P. (author)
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Hampel, H. (author)
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Vanderstichele, H. (author)
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Iqbal, K. (author)
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Galasko, D. (author)
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- Lannfelt, Lars (author)
- Uppsala universitet,Geriatrik
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Otto, M. (author)
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Esselman, H. (author)
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Henkel, A. W. (author)
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Kornhuber, J. (author)
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Blennow, K. (author)
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(creator_code:org_t)
- 2009
- 2009
- English.
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In: Revista de Psiquiatria Clinica. - 0101-6083. ; 36, s. 1-16
- Related links:
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https://urn.kb.se/re...
Abstract
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- Aging of population, and increasing life expectancy result in an increasing number of patients with dementia. This symptom can be a part of a completely curable disease of the central nervous system (e.g, neuroinflammation), or a disease currently considered irreversible (e.g, Alzheimer's disease, AD). In the latter case, several potentially successful treatment approaches are being tested now, demanding reasonable standards of pre-mortem diagnosis. Cerebrospinal fluid and serum analysis (CSF/serum analysis), whereas routinely performed in neuroinflammatory diseases, still requires standardization to be used as an aid to the clinically based diagnosis of AD. Several AD-related CSF parameters (total tau, phosphorylated forms of tau, A beta peptides, ApoE genotype, p97, etc.) tested separately or in a combination provide sensitivity and specificity in the range of 85%, the figure commonly expected from a good diagnostic tool. In this review, recently published reports regarding progress in neurochemical pre-mortem diagnosis of dementias are discussed with a focus on an early and differential diagnosis of AD. Novel perspectives offered by recently introduced technologies, e.g, fluorescence correlation spectroscopy (FCS) and surface enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF MS) are briefly discussed.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
Keyword
- Dementia
- Alzheimer's disease
- neuroinflammation
- cerebrospinal fluid
- Psychiatry
- Psykiatri
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- By the author/editor
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Wiltfang, J.
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Lewczuk, P.
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Riederer, P.
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Gruenblatt, E.
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Hock, C.
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Scheltens, P.
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show more...
-
Hampel, H.
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Vanderstichele, ...
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Iqbal, K.
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Galasko, D.
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Lannfelt, Lars
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Otto, M.
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Esselman, H.
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Henkel, A. W.
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Kornhuber, J.
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Blennow, K.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Psychiatry
- Articles in the publication
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Revista de Psiqu ...
- By the university
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Uppsala University