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Ten years with biol...
Ten years with biologics : to whom do data on effectiveness and safety apply?
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- Simard, Julia F. (author)
- Karolinska Institutet,Karolinska Institute
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- Arkema, Elizabeth V. (author)
- Karolinska Institutet,Lund University
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- Sundström, Anders (author)
- Karolinska Institutet
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- Geborek, Pierre (author)
- Lund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Saxne, Tore (author)
- Lund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Baecklund, Eva (author)
- Uppsala universitet,Reumatologi,Uppsala University
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- Cöster, Lars (author)
- Östergötlands Läns Landsting,Linköpings universitet,Reumatologi,Hälsouniversitetet,Länskliniken för Reumatologi i Östergötland
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- Dackhammar, Christina (author)
- Sahlgrens University Hospital
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- Jacobsson, Lennart (author)
- Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups
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- Feltelius, Nils (author)
- Medical Product Agency, Uppsala
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- Lindblad, Staffan (author)
- Karolinska Institutet,Karolinska Institute
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- Rantapää-Dahlqvist, Solbritt (author)
- Umeå universitet,Reumatologi,Umea University, Department Med, Rheumatol Unit, University Hospital, Umea, Sweden
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- Klareskog, Lars (author)
- Karolinska Institutet,Karolinska Institute, Karolinska University Hospital, Department Med, Rheumatol Unit, S-17176 Stockholm, Sweden
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- van Vollenhoven, Ronald F. (author)
- Karolinska Institutet,Karolinska Institute
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- Neovius, Martin (author)
- Karolinska Institutet,Karolinska Institute
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- Askling, Johan (author)
- Karolinska Institutet
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(creator_code:org_t)
- 2010-11-16
- 2011
- English.
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In: Rheumatology. - : Oxford University Press (OUP). - 1462-0324 .- 1462-0332. ; 50:1, s. 204-213
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Abstract
Subject headings
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- Methods. We identified all adult patients with RA (n = 9612), PsA (n = 1417) and other SpA (n = 1652) initiating a first biologic therapy between 1 January 1999 and 31 December 2008, registered in the Swedish Biologics Register (ARTIS), including information on demographics, disease characteristics and 1-year risk of first-line treatment discontinuation. Results. Over calendar time, measures of disease activity at start declined substantially for all indications, and diminished between first-, second- and third-line therapy starts. One-year risks of first-line therapy discontinuation increased. Switchers to anti-TNF and non-TNF biologics had different comorbidities. Despite < 50% drug retention at 5 years, most patients remained exposed to some biologic. Conclusions. The trends in baseline characteristics and drug retention underscores that any effects of biologics, including comparison between different biologics, must be interpreted in light of the characteristics of the population treated. The observed differences further call for continued vigilance to properly evaluate the safety profiles of biologic treatments as they are currently used. Exposure to multiple biologics presents a challenge for attribution of long-term effects.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
Keyword
- Biologics
- Rheumatoid arthritis
- Anti-tumour necrosis factor
- Psoriatic arthritis
- Spondylarthritides
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Simard, Julia F.
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Arkema, Elizabet ...
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Sundström, Ander ...
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Geborek, Pierre
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Saxne, Tore
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Baecklund, Eva
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show more...
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Cöster, Lars
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Dackhammar, Chri ...
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Jacobsson, Lenna ...
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Feltelius, Nils
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Lindblad, Staffa ...
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Rantapää-Dahlqvi ...
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Klareskog, Lars
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van Vollenhoven, ...
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Neovius, Martin
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Askling, Johan
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Rheumatology and ...
- Articles in the publication
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Rheumatology
- By the university
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Uppsala University
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Umeå University
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Lund University
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Karolinska Institutet
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Linköping University