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Increased mRNA Leve...
Increased mRNA Levels of TCF7L2 and MYC of the Wnt Pathway in Tg-ArcSwe Mice and Alzheimer's Disease Brain
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- Blom, Elin S (author)
- Uppsala universitet,Institutionen för folkhälso- och vårdvetenskap,Molekylär geriatrik
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- Wang, Yijing (author)
- Uppsala universitet,Institutionen för folkhälso- och vårdvetenskap,Molekylär geriatrik
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- Skoglund, Lena (author)
- Uppsala universitet,Institutionen för folkhälso- och vårdvetenskap,Molekylär geriatrik
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show more...
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Hansson, Anita C (author)
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Ubaldi, Massimo (author)
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Lourdusamy, Anbarasu (author)
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Sommer, Wolfgang H (author)
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Mielke, Matthew (author)
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Hyman, Bradley T (author)
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Heilig, Markus (author)
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- Lannfelt, Lars (author)
- Uppsala universitet,Institutionen för folkhälso- och vårdvetenskap,Molekylär geriatrik
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- Nilsson, Lars N G (author)
- Uppsala universitet,Institutionen för folkhälso- och vårdvetenskap,Molekylär geriatrik
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- Ingelsson, Martin (author)
- Uppsala universitet,Institutionen för folkhälso- och vårdvetenskap,Molekylär geriatrik
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(creator_code:org_t)
- Hindawi Limited, 2010
- 2010
- English.
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In: International journal of Alzheimer's disease. - : Hindawi Limited. - 2090-0252 .- 2090-8024. ; 2011, s. 936580-
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Abstract
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- Several components in the Wnt pathway, including β-catenin and glycogen synthase kinase 3 beta, have been implied in AD pathogenesis. Here, mRNA brain levels from five-month-old tg-ArcSwe and nontransgenic mice were compared using Affymetrix microarray analysis. With surprisingly small overall changes, Wnt signaling was the most affected pathway with altered expression of nine genes in tg-ArcSwe mice. When analyzing mRNA levels of these genes in human brain, transcription factor 7-like 2 (TCF7L2) and v-myc myelocytomatosis viral oncogene homolog (MYC), were increased in Alzheimer's disease (AD) (P < .05). Furthermore, no clear differences in TCF7L2 and MYC mRNA were found in brains with frontotemporal lobar degeneration, suggesting that altered regulation of these Wnt-related genes could be specific to AD. Finally, mRNA levels of three neurogenesis markers were analyzed. Increased mRNA levels of dihydropyrimidinase-like 3 were observed in AD brain, suggesting that altered Wnt pathway regulation may signify synaptic rearrangement or neurogenesis.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
Keyword
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Blom, Elin S
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Wang, Yijing
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Skoglund, Lena
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Hansson, Anita C
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Ubaldi, Massimo
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Lourdusamy, Anba ...
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show more...
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Sommer, Wolfgang ...
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Mielke, Matthew
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Hyman, Bradley T
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Heilig, Markus
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Lannfelt, Lars
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Nilsson, Lars N ...
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Ingelsson, Marti ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Medical Genetics
- Articles in the publication
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International jo ...
- By the university
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Uppsala University
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Högskolan Dalarna