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Diagnostic threshol...
Diagnostic thresholds for ambulatory blood pressure monitoring based on 10-year cardiovascular risk
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Kikuya, Masahiro (author)
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Hansen, Tine W. (author)
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Thijs, Lutgarde (author)
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- Björklund-Bodegård, Kristina (author)
- Uppsala universitet,Geriatrik,Institutionen för folkhälso- och vårdvetenskap
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Kuznetsova, Tatiana (author)
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Ohkubo, Takayoshi (author)
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Richart, Tom (author)
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Torp-Pedersen, Christian (author)
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- Lind, Lars (author)
- Uppsala universitet,Geriatrik,Institutionen för medicinska vetenskaper
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Ibsen, Hans (author)
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Imai, Yutaka (author)
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Staessen, Jan A. (author)
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(creator_code:org_t)
- 2007
- 2007
- English.
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In: Circulation. - 0009-7322 .- 1524-4539. ; 12:6, s. 393-395
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
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- Background - Current diagnostic thresholds for ambulatory blood pressure ( ABP) mainly rely on statistical parameters derived from reference populations. We determined an outcome-driven reference frame for ABP measurement. Methods and Results - We performed 24-hour ABP monitoring in 5682 participants ( mean age 59.0 years; 43.3% women) enrolled in prospective population studies in Copenhagen, Denmark; Noorderkempen, Belgium; Ohasama, Japan; and Uppsala, Sweden. In multivariate analyses, we determined ABP thresholds, which yielded 10-year cardiovascular risks similar to those associated with optimal ( 120/80 mm Hg), normal ( 130/85 mm Hg), and high ( 140/90 mm Hg) blood pressure on office measurement. Over 9.7 years ( median), 814 cardiovascular end points occurred, including 377 strokes and 435 cardiac events. Systolic/diastolic thresholds for optimal ABP were 116.8/74.2 mm Hg for 24 hours, 121.6/78.9 mm Hg for daytime, and 100.9/65.3 mm Hg for nighttime. Corresponding thresholds for normal ABP were 123.9/76.8, 129.9/82.6, and 110.2/68.1 mm Hg, respectively, and those for ambulatory hypertension were 131.0/79.4, 138.2/86.4, and 119.5/70.8 mm Hg. After rounding, approximate thresholds for optimal ABP amounted to 115/75 mm Hg for 24 hours, 120/80 mm Hg for daytime, and 100/65 mm Hg for nighttime. Rounded thresholds for normal ABP were 125/75, 130/85, and 110/70 mm Hg, respectively, and those for ambulatory hypertension were 130/80, 140/85, and 120/70 mm Hg. Conclusions - Population-based outcome-driven thresholds for optimal and normal ABP are lower than those currently proposed by hypertension guidelines.
Keyword
- blood pressure monitoring
- ambulatory
- blood pressure
- hypertension
- cardiovascular diseases
- epidemiology
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Kikuya, Masahiro
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Hansen, Tine W.
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Thijs, Lutgarde
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Björklund-Bodegå ...
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Kuznetsova, Tati ...
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Ohkubo, Takayosh ...
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show more...
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Richart, Tom
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Torp-Pedersen, C ...
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Lind, Lars
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Ibsen, Hans
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Imai, Yutaka
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Staessen, Jan A.
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show less...
- Articles in the publication
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Circulation
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Blood Pressure M ...
- By the university
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Uppsala University