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Intakes of vitamins...
Intakes of vitamins A, C, and E and use of multiple vitamin supplements and risk of colon cancer : a pooled analysis of prospective cohort studies
- Article/chapterEnglish2010
Publisher, publication year, extent ...
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2010-09-05
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Springer Science and Business Media LLC,2010
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:uu-147249
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-147249URI
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https://doi.org/10.1007/s10552-010-9549-yDOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:121497223URI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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To evaluate the associations between intakes of vitamins A, C, and E and risk of colon cancer. Using the primary data from 13 cohort studies, we estimated study- and sex-specific relative risks (RR) with Cox proportional hazards models and subsequently pooled RRs using a random effects model. Among 676,141 men and women, 5,454 colon cancer cases were identified (7-20 years of follow-up across studies). Vitamin A, C, and E intakes from food only were not associated with colon cancer risk. For intakes from food and supplements (total), the pooled multivariate RRs (95% CI) were 0.88 (0.76-1.02, > 4,000 vs. a parts per thousand currency sign1,000 mu g/day) for vitamin A, 0.81 (0.71-0.92, > 600 vs. a parts per thousand currency sign100 mg/day) for vitamin C, and 0.78 (0.66-0.92, > 200 vs. a parts per thousand currency sign6 mg/day) for vitamin E. Adjustment for total folate intake attenuated these associations, but the inverse associations with vitamins C and E remained significant. Multivitamin use was significantly inversely associated with colon cancer risk (RR = 0.88, 95% CI: 0.81-0.96). Modest inverse associations with vitamin C and E intakes may be due to high correlations with folate intake, which had a similar inverse association with colon cancer. An inverse association with multivitamin use, a major source of folate and other vitamins, deserves further study.
Subject headings and genre
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Vitamin A
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Vitamin C
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Vitamin E
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Multivitamin
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Colon cancer
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Cohort study
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Pooled analysis
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MEDICINE
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MEDICIN
Added entries (persons, corporate bodies, meetings, titles ...)
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Spiegelman, Donna
(author)
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Hunter, David J.
(author)
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Albanes, Demetrius
(author)
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Bergkvist, LeifUppsala universitet,Centrum för klinisk forskning, Västerås(Swepub:uu)leber451
(author)
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Buring, Julie E.
(author)
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Freudenheim, Jo L.
(author)
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Giovannucci, Edward
(author)
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Goldbohm, R. Alexandra
(author)
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Harnack, Lisa
(author)
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Kato, Ikuko
(author)
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Krogh, Vittorio
(author)
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Leitzmann, Michael F.
(author)
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Limburg, Paul J.
(author)
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Marshall, James R.
(author)
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McCullough, Marjorie L.
(author)
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Miller, Anthony B.
(author)
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Rohan, Thomas E.
(author)
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Schatzkin, Arthur
(author)
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Shore, Roy
(author)
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Sieri, Sabina
(author)
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Stampfer, Meir J.
(author)
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Virtamo, Jarmo
(author)
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Weijenberg, Matty
(author)
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Willett, Walter C.
(author)
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Wolk, AlicjaKarolinska Institutet
(author)
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Zhang, Shumin M.
(author)
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Smith-Warner, Stephanie A.
(author)
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Uppsala universitetCentrum för klinisk forskning, Västerås
(creator_code:org_t)
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In:Cancer Causes and Control: Springer Science and Business Media LLC21:11, s. 1745-17570957-52431573-7225
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Albanes, Demetri ...
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Krogh, Vittorio
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