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No prognostic signi...
No prognostic significance of chronic infection with Chlamydia pneumoniae in acute coronary syndromes : insights from the Global Utilization of Strategies to Open Occluded Arteries IV Acute Coronary Syndromes trial
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Westerhout, Cynthia M. (author)
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Gnarpe, Judy (author)
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Chang, Wei-Ching (author)
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FitzPatrick, Susan (author)
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Barnathan, Elliot S. (author)
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Boersma, Eric (author)
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Califf, Robert M. (author)
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- Wallentin, Lars (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper
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Simoons, Maarten L. (author)
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Armstrong, Paul W. (author)
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(creator_code:org_t)
- Elsevier BV, 2007
- 2007
- English.
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In: American Heart Journal. - : Elsevier BV. - 0002-8703 .- 1097-6744. ; 154:2, s. 306-312
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- BACKGROUND: Although relationships between chronic Chlamydia pneumoniae (Cpn) infection and the risk of coronary events in stable coronary artery disease patients have been reported, a similar link in acute coronary syndrome (ACS) patients has not been consistently observed. METHODS: In a nested case-control substudy of the Global Utilization of Strategies to Open Occluded Arteries IV Acute Coronary Syndromes trial, 295 cases (30-day death/myocardial infarction [MI]) were matched by age, sex, baseline creatine kinase-myocardial kinase, and smoking status with 295 control subjects. To test the hypothesis on 1-year mortality, another subset (n = 276) was drawn from the 590-patient cohort; 138 patients who died at 1 year plus the matching controls who survived at 1 year. We measured Cpn IgG and IgA antibody titers in baseline serum with microimmunofluorescence. Conditional logistic regression was used to quantify the prognostic relevance seropositivity (IgG > or = 1:32; IgA > or = 1:16) and elevated titer levels. RESULTS: The prevalence of Cpn IgG and IgA was similar between cases and controls (30-day death/MI: IgG, 80% vs 85%, P = .126; IgA, 45% vs 37%, P = .079), and were not statistically significant predictors of 30-day death/MI after baseline adjustment. Likewise, the 1-year death cohort had comparable proportions of Cpn IgG and IgA among cases and controls (86% vs 91% [P = .265] and 49% vs 43% [P = .334], respectively), and did not add prognostic value. CONCLUSIONS: These findings are in concert with study results suggesting that chronic Cpn infection is not associated with 30-day death/MI or 1-year mortality in non-ST elevation ACS.
Keyword
- MEDICINE
- MEDICIN
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- ref (subject category)
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Westerhout, Cynt ...
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Gnarpe, Judy
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Chang, Wei-Ching
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FitzPatrick, Sus ...
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Barnathan, Ellio ...
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Boersma, Eric
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show more...
-
Califf, Robert M ...
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Wallentin, Lars
-
Simoons, Maarten ...
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Armstrong, Paul ...
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show less...
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American Heart J ...
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Uppsala University