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Is efficiency of suppressor tRNAs controlled at the level of ribosomal proofreading in vivo?
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- Faxén, Margareta (author)
- Uppsala universitet,Mikrobiologi
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- Kirsebom, Leif A (author)
- Uppsala universitet,Mikrobiologi,Kirsebom
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- Isaksson, Leif A (author)
- Uppsala universitet,Mikrobiologi
- (creator_code:org_t)
- 1988
- 1988
- English.
- In: Journal of Bacteriology. - 0021-9193 .- 1098-5530. ; 170:8, s. 3756-3760
- Journal article (peer-reviewed)
Abstract
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- Ribosomal rpsD mutations did not stimulate nonsense suppressor tRNAs in a general manner according to their increased ribosomal ambiguity and decreased proofreading efficiency. Streptomycin, which stimulates error production by blocking proofreading in vitro, did not increase efficiency of suppressor tRNAs in strains with normal or streptomycin-resistant (rpsL) ribosomes. It did so only in combination with one rpsL mutation which is associated with streptomycin pseudodependence.
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- NATURAL SCIENCES
- NATURVETENSKAP
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- art (subject category)
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