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Opioid receptor ago...
Opioid receptor agonist Eribis peptide 94 reduces infarct size in different porcine models for myocardial ischaemia and reperfusion
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- Karlsson, Lars O, 1975 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine,Univ Gothenburg, Sweden
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- Grip, Lars, 1952 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine,Univ Gothenburg, Sweden
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- Bissessar, Erik (author)
- Eribis Pharmaceut AB, Sweden
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- Bobrova, Irina (author)
- Eribis Pharmaceut AB, Sweden
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- Gustafsson, Thomas (author)
- Karolinska Institutet,Karolinska Univ Hosp, Sweden
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- Kavianipour, Mohammad (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Univ Uppsala Hosp, Sweden
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- Odenstedt, Jacob, 1968 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine,Univ Gothenburg, Sweden
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- Wikström, Gerhard (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Univ Uppsala Hosp, Sweden
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- Gonon, Adrian T. (author)
- Karolinska Institutet,Karolinska Univ Hosp, Sweden
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(creator_code:org_t)
- Elsevier BV, 2011
- 2011
- English.
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In: European Journal of Pharmacology. - : Elsevier BV. - 0014-2999 .- 1879-0712. ; 651:1-3, s. 146-151
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Abstract
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- Eribis peptide 94 (EP 94) is a novel enkephalin analog, thought to interact with the and delta-opioid receptors. The purpose of the present study was to examine the cardioprotective potential of EP 94 in two clinically relevant porcine models of myocardial ischaemia and reperfusion, and to investigate if such an effect is associated with an increased expression of endothelial nitric oxide synthase (eNOS). Forty-one anesthetized pigs underwent 40 min of coronary occlusion followed by 4 h of reperfusion. In Protocol I, balloon occlusion of the left anterior descending artery was performed with concurrent intravenous administration of (A) vehicle (n = 7), (B) EP 94 (1 ug/kg) after 5, 12, 19 and 26 min of ischaemia (n = 4) or (C) EP 94 (1 ug/kg) after 26, 33, 40 min of ischaemia (n = 6). In Protocol II, open-chest pigs were administered (D) vehicle (n = 6) or (E) 0.2 ug/kg/min of EP 94 (n = 6) through an intracoronary infusion into the jeopardized myocardium, started after 30 min of ischaemia and maintained for 15 min. The hearts were stained and the protein content of eNOS measured. EP 94 reduces infarct size when administered both early and late during ischaemia compared with vehicle (infarct size group A 61.6 +/- 2%, group B 50.2 +/- 3% and group C 49.2 +/- 2%, respectively, P < 0.05), as well as when infused intracoronary (infarct size group D 82.2 +/- 3.9% and group E 61.2 +/- 2.5% respectively, P < 0.01). Phosphorylated eNOS Ser(I177) in relation to total eNOS was significantly increased in the group administered EP 94. indicating activation of nitric oxide production.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmaceutiska vetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmaceutical Sciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Dermatologi och venereologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Dermatology and Venereal Diseases (hsv//eng)
Keyword
- Reperfusion injury
- Myocardial ischaemia
- Nitric oxide
- Opioid receptor
- Porcine
- PHARMACY
- FARMACI
- Reperfusion injury; Myocardial ischaemia; Nitric oxide; Opioid receptor; Porcine
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Karlsson, Lars O ...
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Grip, Lars, 1952
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Bissessar, Erik
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Bobrova, Irina
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Gustafsson, Thom ...
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Kavianipour, Moh ...
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show more...
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Odenstedt, Jacob ...
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Wikström, Gerhar ...
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Gonon, Adrian T.
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Pharmaceutical S ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Dermatology and ...
- Articles in the publication
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European Journal ...
- By the university
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Uppsala University
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University of Gothenburg
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Karolinska Institutet
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Linköping University