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  • Gordh, Torsten EUppsala universitet,Anestesiologi och intensivvård,Multidisciplinary Pain Center, Uppsala University Hospital, S-751 85 Uppsala, Sweden (author)

Gabapentin in traumatic nerve injury pain : a randomized, double-blind, placebo-controlled, cross-over, multi-center study

  • Article/chapterEnglish2008

Publisher, publication year, extent ...

  • Ovid Technologies (Wolters Kluwer Health),2008
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-148186
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-148186URI
  • https://doi.org/10.1016/j.pain.2007.12.011DOI
  • https://lup.lub.lu.se/record/1286584URI
  • https://gup.ub.gu.se/publication/74063URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-50453URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • A double-blind, randomized, placebo-controlled cross-over multi-center study was conducted to evaluate the efficacy and safety of gabapentin in the treatment of neuropathic pain caused by traumatic or postsurgical peripheral nerve injury, using doses up to 2400 mg/day. The study comprised a run-in period of two weeks, two treatment periods of five weeks separated by a three weeks' washout period. The primary efficacy variable was the change in the mean pain intensity score from baseline to the last week of treatment. Other variables included pain relief, health related quality of life (SF-36), interference of sleep by pain, Clinician and Patient Global Impression of Change, and adverse effects. Nine centers randomized a total of 120 patients, 22 of whom withdrew. There was no statistically significant difference between the treatments for the primary outcome efficacy variable. However, gabapentin provided significantly better pain relief (p=0.015) compared with placebo. More patients had at least a 30% pain reduction with gabapentin compared with placebo (p=0.040) and pain interfered significantly less with sleep during gabapentin treatment compared with placebo (p=0.0016). Both the Patient (p=0.023) and Clinician (p=0.037) Global Impression of Change indicated a better response with gabapentin compared with placebo. Gabapentin was well tolerated. The most common adverse effects were dizziness and tiredness.

Subject headings and genre

  • Neuropathic pain
  • Traumatic nerve injury
  • Gabapentin
  • Randomized controlled cross-over trial
  • MEDICINE
  • MEDICIN
  • controlled cross-over trial
  • randomized
  • gabapentin
  • neuropathic pain
  • traumatic nerve injury

Added entries (persons, corporate bodies, meetings, titles ...)

  • Stubhaug, AudunDepartment of Anaesthesiology, University of Oslo, Rikshospitalet University Hospital, 0027 Oslo, Norway (author)
  • Jensen, Troels SDepartment of Neurology, Danish Pain Research Centre, Aarhus University Hospital, Aarhus, 8000, Denmark (author)
  • Arnèr, StaffanArnèr, S., Pain Clinic, Department of Anaesthesiology, Karolinska University Hospital, Solna, S-171 76 Stockholm, Sweden (author)
  • Biber, Björn,1944Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för anestesiologi och intensivvård,Institute of Clinical Sciences, Department of Anesthesiology and Intensive care,Department of Anaestesiology, Umeå University Hospital, S-901 85 Umeå, Sweden(Swepub:gu)xbibbj (author)
  • Boivie, JörgenÖstergötlands Läns Landsting,Linköpings universitet,Hälsouniversitetet,Neurologi,Neurologiska kliniken(Swepub:liu)jorbo29 (author)
  • Mannheimer, Clas,1942Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för akut och kardiovaskulär medicin,Institute of Medicine, Department of Emergeny and Cardiovascular Medicine,Multidisciplinary Pain Center, Department of Medicine, Sahlgrenska University Hospital, Östra, 41685 Göteborg, Sweden(Swepub:gu)xmancl (author)
  • Kalliomaki, JarkkoLund University,Lunds universitet,Rehabiliteringsmedicin,Forskargrupper vid Lunds universitet,Rehabilitation medicine,Lund University Research Groups,Kalliomäki, J., Department of Rehabilitation, Lund University Hospital, S-221 85 Lund, Sweden(Swepub:lu)extLU-148 (author)
  • Kalso, EijaPain Clinic, Department of Anaesthesiology and Intensive Care Medicine, Helsinki University Central Hospital, Haartmaninkatu 2A, 00029 HUS, Finland (author)
  • Uppsala universitetAnestesiologi och intensivvård (creator_code:org_t)

Related titles

  • In:Pain: Ovid Technologies (Wolters Kluwer Health)138:2, s. 255-2660304-39591872-6623

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